TP53 Polymorphisms allow for genetic sub-grouping of the canine transmissible venereal tumor

The canine transmissible venereal tumor (CTVT) is found mainly in dogs' sexual organs. Currently, it is widely accepted that all samples of CTVT show similar histopathological characteristics and share common genetic alterations. Despite the common genetic origin of CTVT, mutations in the P53 g...

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Detalles Bibliográficos
Autores principales: Sánchez-Servín, Abel, Martínez, Simón, Córdova-Alarcon, Emilio, Fajardo, Raúl
Formato: Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2009
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807274/
https://www.ncbi.nlm.nih.gov/pubmed/19934603
http://dx.doi.org/10.4142/jvs.2009.10.4.353
Descripción
Sumario:The canine transmissible venereal tumor (CTVT) is found mainly in dogs' sexual organs. Currently, it is widely accepted that all samples of CTVT show similar histopathological characteristics and share common genetic alterations. Despite the common genetic origin of CTVT, mutations in the P53 gene have been reported. In this study, we proposed that tumor samples can be genetically grouped using this gene. The presence of different subgroups of CTVT was determined in Mexican dogs using the TP53 gene sequence in CTVT samples. Four new polymorphisms were found and therefore, the CTVT samples were classified in five subgroups.

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