TP53 Polymorphisms allow for genetic sub-grouping of the canine transmissible venereal tumor

The canine transmissible venereal tumor (CTVT) is found mainly in dogs' sexual organs. Currently, it is widely accepted that all samples of CTVT show similar histopathological characteristics and share common genetic alterations. Despite the common genetic origin of CTVT, mutations in the P53 g...

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Autores principales: Sánchez-Servín, Abel, Martínez, Simón, Córdova-Alarcon, Emilio, Fajardo, Raúl
Formato: Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2009
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807274/
https://www.ncbi.nlm.nih.gov/pubmed/19934603
http://dx.doi.org/10.4142/jvs.2009.10.4.353
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author Sánchez-Servín, Abel
Martínez, Simón
Córdova-Alarcon, Emilio
Fajardo, Raúl
author_facet Sánchez-Servín, Abel
Martínez, Simón
Córdova-Alarcon, Emilio
Fajardo, Raúl
author_sort Sánchez-Servín, Abel
collection PubMed
description The canine transmissible venereal tumor (CTVT) is found mainly in dogs' sexual organs. Currently, it is widely accepted that all samples of CTVT show similar histopathological characteristics and share common genetic alterations. Despite the common genetic origin of CTVT, mutations in the P53 gene have been reported. In this study, we proposed that tumor samples can be genetically grouped using this gene. The presence of different subgroups of CTVT was determined in Mexican dogs using the TP53 gene sequence in CTVT samples. Four new polymorphisms were found and therefore, the CTVT samples were classified in five subgroups.
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spelling pubmed-28072742010-01-15 TP53 Polymorphisms allow for genetic sub-grouping of the canine transmissible venereal tumor Sánchez-Servín, Abel Martínez, Simón Córdova-Alarcon, Emilio Fajardo, Raúl J Vet Sci Short Communication The canine transmissible venereal tumor (CTVT) is found mainly in dogs' sexual organs. Currently, it is widely accepted that all samples of CTVT show similar histopathological characteristics and share common genetic alterations. Despite the common genetic origin of CTVT, mutations in the P53 gene have been reported. In this study, we proposed that tumor samples can be genetically grouped using this gene. The presence of different subgroups of CTVT was determined in Mexican dogs using the TP53 gene sequence in CTVT samples. Four new polymorphisms were found and therefore, the CTVT samples were classified in five subgroups. The Korean Society of Veterinary Science 2009-12 2009-11-26 /pmc/articles/PMC2807274/ /pubmed/19934603 http://dx.doi.org/10.4142/jvs.2009.10.4.353 Text en Copyright © 2009 The Korean Society of Veterinary Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Sánchez-Servín, Abel
Martínez, Simón
Córdova-Alarcon, Emilio
Fajardo, Raúl
TP53 Polymorphisms allow for genetic sub-grouping of the canine transmissible venereal tumor
title TP53 Polymorphisms allow for genetic sub-grouping of the canine transmissible venereal tumor
title_full TP53 Polymorphisms allow for genetic sub-grouping of the canine transmissible venereal tumor
title_fullStr TP53 Polymorphisms allow for genetic sub-grouping of the canine transmissible venereal tumor
title_full_unstemmed TP53 Polymorphisms allow for genetic sub-grouping of the canine transmissible venereal tumor
title_short TP53 Polymorphisms allow for genetic sub-grouping of the canine transmissible venereal tumor
title_sort tp53 polymorphisms allow for genetic sub-grouping of the canine transmissible venereal tumor
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807274/
https://www.ncbi.nlm.nih.gov/pubmed/19934603
http://dx.doi.org/10.4142/jvs.2009.10.4.353
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