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Pathogenicity and antigenicity of a new variant of Korean nephropathogenic infectious bronchitis virus

Despite the existence of an active vaccination program, recently emerged strains of nephropathogenic infectious bronchitis virus (IBV) in Korea have caused significant economic losses in the poultry industry. In this study, we assessed the pathogenic and antigenic characteristics of a K-IIb type fie...

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Autores principales: Choi, Kang-Seuk, Lee, Eun-Kyoung, Jeon, Woo-Jin, Park, Mi-Ja, Kim, Jin-Won, Kwon, Jun-Hun
Formato: Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807275/
https://www.ncbi.nlm.nih.gov/pubmed/19934604
http://dx.doi.org/10.4142/jvs.2009.10.4.357
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author Choi, Kang-Seuk
Lee, Eun-Kyoung
Jeon, Woo-Jin
Park, Mi-Ja
Kim, Jin-Won
Kwon, Jun-Hun
author_facet Choi, Kang-Seuk
Lee, Eun-Kyoung
Jeon, Woo-Jin
Park, Mi-Ja
Kim, Jin-Won
Kwon, Jun-Hun
author_sort Choi, Kang-Seuk
collection PubMed
description Despite the existence of an active vaccination program, recently emerged strains of nephropathogenic infectious bronchitis virus (IBV) in Korea have caused significant economic losses in the poultry industry. In this study, we assessed the pathogenic and antigenic characteristics of a K-IIb type field strain of IBV that emerged in Korea since 2003, such as Kr/Q43/06. Specific pathogen free 1-week-old chickens exhibited severe respiratory symptoms (dyspnea) and nephropathogenic lesions (swollen kidneys with nephritis and urate deposits) following challenge with the recent IBV field strain. The antigenic relatedness (R value), based on a calculated virus neutralization index, of the K-IIb type field strain and K-IIa type strain KM91 (isolated in 1991) was 30%, which indicated that the recent strain, Kr/Q43/06, is a new variant that is antigenically distinct from strain KM91. This report is the first to document the emergence of a new antigenic variant of nephropathogenic IBV in chicken from Korea.
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spelling pubmed-28072752010-01-15 Pathogenicity and antigenicity of a new variant of Korean nephropathogenic infectious bronchitis virus Choi, Kang-Seuk Lee, Eun-Kyoung Jeon, Woo-Jin Park, Mi-Ja Kim, Jin-Won Kwon, Jun-Hun J Vet Sci Short Communication Despite the existence of an active vaccination program, recently emerged strains of nephropathogenic infectious bronchitis virus (IBV) in Korea have caused significant economic losses in the poultry industry. In this study, we assessed the pathogenic and antigenic characteristics of a K-IIb type field strain of IBV that emerged in Korea since 2003, such as Kr/Q43/06. Specific pathogen free 1-week-old chickens exhibited severe respiratory symptoms (dyspnea) and nephropathogenic lesions (swollen kidneys with nephritis and urate deposits) following challenge with the recent IBV field strain. The antigenic relatedness (R value), based on a calculated virus neutralization index, of the K-IIb type field strain and K-IIa type strain KM91 (isolated in 1991) was 30%, which indicated that the recent strain, Kr/Q43/06, is a new variant that is antigenically distinct from strain KM91. This report is the first to document the emergence of a new antigenic variant of nephropathogenic IBV in chicken from Korea. The Korean Society of Veterinary Science 2009-12 2009-11-26 /pmc/articles/PMC2807275/ /pubmed/19934604 http://dx.doi.org/10.4142/jvs.2009.10.4.357 Text en Copyright © 2009 The Korean Society of Veterinary Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Choi, Kang-Seuk
Lee, Eun-Kyoung
Jeon, Woo-Jin
Park, Mi-Ja
Kim, Jin-Won
Kwon, Jun-Hun
Pathogenicity and antigenicity of a new variant of Korean nephropathogenic infectious bronchitis virus
title Pathogenicity and antigenicity of a new variant of Korean nephropathogenic infectious bronchitis virus
title_full Pathogenicity and antigenicity of a new variant of Korean nephropathogenic infectious bronchitis virus
title_fullStr Pathogenicity and antigenicity of a new variant of Korean nephropathogenic infectious bronchitis virus
title_full_unstemmed Pathogenicity and antigenicity of a new variant of Korean nephropathogenic infectious bronchitis virus
title_short Pathogenicity and antigenicity of a new variant of Korean nephropathogenic infectious bronchitis virus
title_sort pathogenicity and antigenicity of a new variant of korean nephropathogenic infectious bronchitis virus
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807275/
https://www.ncbi.nlm.nih.gov/pubmed/19934604
http://dx.doi.org/10.4142/jvs.2009.10.4.357
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