Splicing of the Mycobacteriophage Bethlehem DnaB Intein: IDENTIFICATION OF A NEW MECHANISTIC CLASS OF INTEINS THAT CONTAIN AN OBLIGATE BLOCK F NUCLEOPHILE

Inteins are single turnover enzymes that splice out of protein precursors during maturation of the host protein (extein). The Cys or Ser at the N terminus of most inteins initiates a four-step protein splicing reaction by forming a (thio)ester bond at the N-terminal splice junction. Several recently...

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Detalles Bibliográficos
Autores principales: Tori, Kazuo, Dassa, Bareket, Johnson, Margaret A., Southworth, Maurice W., Brace, Lear E., Ishino, Yoshizumi, Pietrokovski, Shmuel, Perler, Francine B.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807308/
https://www.ncbi.nlm.nih.gov/pubmed/19940146
http://dx.doi.org/10.1074/jbc.M109.069567

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