Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours

Mixed lineage kinase 3 (MLK3) is a serine/threonine kinase, regulating MAPkinase signalling, in which cancer-associated mutations have never been reported. In this study, 174 primary gastrointestinal cancers (48 hereditary and 126 sporadic forms) and 7 colorectal cancer cell lines were screened for...

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Detalles Bibliográficos
Autores principales: Velho, Sérgia, Oliveira, Carla, Paredes, Joana, Sousa, Sónia, Leite, Marina, Matos, Paulo, Milanezi, Fernanda, Ribeiro, Ana Sofia, Mendes, Nuno, Licastro, Danilo, Karhu, Auli, Oliveira, Maria José, Ligtenberg, Marjolijn, Hamelin, Richard, Carneiro, Fátima, Lindblom, Annika, Peltomaki, Paivi, Castedo, Sérgio, Schwartz, Simó, Jordan, Peter, Aaltonen, Lauri A., Hofstra, Robert M.W., Suriano, Gianpaolo, Stupka, Elia, Fialho, Arsenio M., Seruca, Raquel
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807374/
https://www.ncbi.nlm.nih.gov/pubmed/19955118
http://dx.doi.org/10.1093/hmg/ddp536

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