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Endothelin receptor antagonist and airway dysfunction in pulmonary arterial hypertension
BACKGROUND: In idiopathic pulmonary arterial hypertension (IPAH), peripheral airway obstruction is frequent. This is partially attributed to the mediator dysbalance, particularly an excess of endothelin-1 (ET-1), to increased pulmonary vascular and airway tonus and to local inflammation. Bosentan (E...
Autores principales: | Droste, Annette S, Rohde, David, Voelkers, Mirko, Filusch, Arthur, Bruckner, Thomas, Borst, Mathias M, Katus, Hugo A, Meyer, F Joachim |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807428/ https://www.ncbi.nlm.nih.gov/pubmed/20042085 http://dx.doi.org/10.1186/1465-9921-10-129 |
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