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Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury

The anterior cingulate cortex (ACC) is important for cognitive and sensory functions including memory and chronic pain. Glutamatergic excitatory synaptic transmission undergo long-term potentiation in ACC pyramidal cells after peripheral injury. Less information is available for the possible long-te...

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Autores principales: Cao, Xiao-Yan, Xu, Hui, Wu, Long-Jun, Li, Xiang-Yao, Chen, Tao, Zhuo, Min
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807858/
https://www.ncbi.nlm.nih.gov/pubmed/20015370
http://dx.doi.org/10.1186/1744-8069-5-73
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author Cao, Xiao-Yan
Xu, Hui
Wu, Long-Jun
Li, Xiang-Yao
Chen, Tao
Zhuo, Min
author_facet Cao, Xiao-Yan
Xu, Hui
Wu, Long-Jun
Li, Xiang-Yao
Chen, Tao
Zhuo, Min
author_sort Cao, Xiao-Yan
collection PubMed
description The anterior cingulate cortex (ACC) is important for cognitive and sensory functions including memory and chronic pain. Glutamatergic excitatory synaptic transmission undergo long-term potentiation in ACC pyramidal cells after peripheral injury. Less information is available for the possible long-term changes in neuronal action potentials or intrinsic properties. In the present study, we characterized cingulate pyramidal cells in the layer II/III of the ACC in adult mice. We then examined possible long-term changes in intrinsic properties of the ACC pyramidal cells after peripheral nerve injury. In the control mice, we found that there are three major types of pyramidal cells according to their action potential firing pattern: (i) regular spiking (RS) cells (24.7%), intrinsic bursting (IB) cells (30.9%), and intermediate (IM) cells (44.4%). In a state of neuropathic pain, the population distribution (RS: 21.3%; IB: 31.2%; IM: 47.5%) and the single action potential properties of these three groups were indistinguishable from those in control mice. However, for repetitive action potentials, IM cells from neuropathic pain animals showed higher initial firing frequency with no change for the properties of RS and IB neurons from neuropathic pain mice. The present results provide the first evidence that, in addition to synaptic potentiation reported previously, peripheral nerve injury produces long-term plastic changes in the action potentials of cingulate pyramidal neurons in a cell type-specific manner.
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spelling pubmed-28078582010-01-19 Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury Cao, Xiao-Yan Xu, Hui Wu, Long-Jun Li, Xiang-Yao Chen, Tao Zhuo, Min Mol Pain Research The anterior cingulate cortex (ACC) is important for cognitive and sensory functions including memory and chronic pain. Glutamatergic excitatory synaptic transmission undergo long-term potentiation in ACC pyramidal cells after peripheral injury. Less information is available for the possible long-term changes in neuronal action potentials or intrinsic properties. In the present study, we characterized cingulate pyramidal cells in the layer II/III of the ACC in adult mice. We then examined possible long-term changes in intrinsic properties of the ACC pyramidal cells after peripheral nerve injury. In the control mice, we found that there are three major types of pyramidal cells according to their action potential firing pattern: (i) regular spiking (RS) cells (24.7%), intrinsic bursting (IB) cells (30.9%), and intermediate (IM) cells (44.4%). In a state of neuropathic pain, the population distribution (RS: 21.3%; IB: 31.2%; IM: 47.5%) and the single action potential properties of these three groups were indistinguishable from those in control mice. However, for repetitive action potentials, IM cells from neuropathic pain animals showed higher initial firing frequency with no change for the properties of RS and IB neurons from neuropathic pain mice. The present results provide the first evidence that, in addition to synaptic potentiation reported previously, peripheral nerve injury produces long-term plastic changes in the action potentials of cingulate pyramidal neurons in a cell type-specific manner. BioMed Central 2009-12-16 /pmc/articles/PMC2807858/ /pubmed/20015370 http://dx.doi.org/10.1186/1744-8069-5-73 Text en Copyright ©2009 Cao et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Cao, Xiao-Yan
Xu, Hui
Wu, Long-Jun
Li, Xiang-Yao
Chen, Tao
Zhuo, Min
Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury
title Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury
title_full Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury
title_fullStr Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury
title_full_unstemmed Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury
title_short Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury
title_sort characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807858/
https://www.ncbi.nlm.nih.gov/pubmed/20015370
http://dx.doi.org/10.1186/1744-8069-5-73
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