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Haemodiafiltration—optimal efficiency and safety

Haemodiafiltration (HDF) is the blood purification therapy of choice for those who want significant removal of uraemic solutes beyond the traditional range of small molecules. Combining diffusive and convective solute transport, a HDF treatment comprises the largest number of variables among blood p...

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Detalles Bibliográficos
Autores principales: Ledebo, Ingrid, Blankestijn, Peter J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808132/
https://www.ncbi.nlm.nih.gov/pubmed/20090878
http://dx.doi.org/10.1093/ndtplus/sfp149
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author Ledebo, Ingrid
Blankestijn, Peter J.
author_facet Ledebo, Ingrid
Blankestijn, Peter J.
author_sort Ledebo, Ingrid
collection PubMed
description Haemodiafiltration (HDF) is the blood purification therapy of choice for those who want significant removal of uraemic solutes beyond the traditional range of small molecules. Combining diffusive and convective solute transport, a HDF treatment comprises the largest number of variables among blood purification therapies, and it is important to understand how they interact in order to optimize the therapy. This review discusses the parameters that determine the efficiency of HDF and how they can be controlled in the different forms of HDF and ‘HDF-like’ therapies practised today. The key to safe and effective HDF therapy is to have access to large volumes of high-quality fluids. Starting with ultrapure dialysis fluid, on-line preparation of a sterile, non-pyrogenic substitution solution can be made an integral part of the treatment, and we describe the necessary conditions for this. On-line HDF can provide the largest removal of the widest range of solutes among available dialysis therapies, and the potential clinical benefits of this are within practical reach for the increasing number of patients dialysed with high-flux membranes and ultrapure dialysis fluid.
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spelling pubmed-28081322010-01-20 Haemodiafiltration—optimal efficiency and safety Ledebo, Ingrid Blankestijn, Peter J. NDT Plus In-Depth Clinical Review Haemodiafiltration (HDF) is the blood purification therapy of choice for those who want significant removal of uraemic solutes beyond the traditional range of small molecules. Combining diffusive and convective solute transport, a HDF treatment comprises the largest number of variables among blood purification therapies, and it is important to understand how they interact in order to optimize the therapy. This review discusses the parameters that determine the efficiency of HDF and how they can be controlled in the different forms of HDF and ‘HDF-like’ therapies practised today. The key to safe and effective HDF therapy is to have access to large volumes of high-quality fluids. Starting with ultrapure dialysis fluid, on-line preparation of a sterile, non-pyrogenic substitution solution can be made an integral part of the treatment, and we describe the necessary conditions for this. On-line HDF can provide the largest removal of the widest range of solutes among available dialysis therapies, and the potential clinical benefits of this are within practical reach for the increasing number of patients dialysed with high-flux membranes and ultrapure dialysis fluid. Oxford University Press 2010-02 2009-11-05 /pmc/articles/PMC2808132/ /pubmed/20090878 http://dx.doi.org/10.1093/ndtplus/sfp149 Text en © The Author 2009. Published by Oxford University Press [on behalf of ERA-EDTA]. http://creativecommons.org/licenses/by-nc/2.5/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle In-Depth Clinical Review
Ledebo, Ingrid
Blankestijn, Peter J.
Haemodiafiltration—optimal efficiency and safety
title Haemodiafiltration—optimal efficiency and safety
title_full Haemodiafiltration—optimal efficiency and safety
title_fullStr Haemodiafiltration—optimal efficiency and safety
title_full_unstemmed Haemodiafiltration—optimal efficiency and safety
title_short Haemodiafiltration—optimal efficiency and safety
title_sort haemodiafiltration—optimal efficiency and safety
topic In-Depth Clinical Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808132/
https://www.ncbi.nlm.nih.gov/pubmed/20090878
http://dx.doi.org/10.1093/ndtplus/sfp149
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