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A Rough Set-Based Model of HIV-1 Reverse Transcriptase Resistome
Reverse transcriptase (RT) is a viral enzyme crucial for HIV-1 replication. Currently, 12 drugs are targeted against the RT. The low fidelity of the RT-mediated transcription leads to the quick accumulation of drug-resistance mutations. The sequence-resistance relationship remains only partially und...
Autores principales: | Kierczak, Marcin, Ginalski, Krzysztof, Dramiński, Michał, Koronacki, Jacek, Rudnicki, Witold, Komorowski, Jan |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808174/ https://www.ncbi.nlm.nih.gov/pubmed/20140064 |
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