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Helicobacter pylori infection is associated with decreased serum levels of high density lipoprotein, but not with the severity of coronary atherosclerosis

OBJECTIVE: The objective of this survey was to study the association between Helicobacter pylori infection and the severity of coronary atherosclerosis. METHODS: The study population consisted of 961 consecutive patients (711 males and 250 females) who underwent coronary angiography for suspected or...

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Autores principales: Jia, En-Zhi, Zhao, Fu-Jun, Hao, Bo, Zhu, Tie-Bing, Wang, Lian-Sheng, Chen, Bo, Cao, Ke-Jiang, Huang, Jun, Ma, Wen-Zhu, Yang, Zhi-Jian, Zhang, Guoxin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808301/
https://www.ncbi.nlm.nih.gov/pubmed/20030806
http://dx.doi.org/10.1186/1476-511X-8-59
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author Jia, En-Zhi
Zhao, Fu-Jun
Hao, Bo
Zhu, Tie-Bing
Wang, Lian-Sheng
Chen, Bo
Cao, Ke-Jiang
Huang, Jun
Ma, Wen-Zhu
Yang, Zhi-Jian
Zhang, Guoxin
author_facet Jia, En-Zhi
Zhao, Fu-Jun
Hao, Bo
Zhu, Tie-Bing
Wang, Lian-Sheng
Chen, Bo
Cao, Ke-Jiang
Huang, Jun
Ma, Wen-Zhu
Yang, Zhi-Jian
Zhang, Guoxin
author_sort Jia, En-Zhi
collection PubMed
description OBJECTIVE: The objective of this survey was to study the association between Helicobacter pylori infection and the severity of coronary atherosclerosis. METHODS: The study population consisted of 961 consecutive patients (711 males and 250 females) who underwent coronary angiography for suspected or known coronary atherosclerosis. The patients' body mass index, blood pressure, the blood lipid, blood glucose, leukocyte count (10(9)/L), neutrophil count (10(9)/L), and Helicobacter pylori-specific IgG antibodies were performed. Coronary angiograms were scored according to vessel score and Gensini's score. RESULTS: A significant association between H. pylori infection and coronary atherosclerosis as well as its severity was not find in this cross section study (p = 0.858). And, the level distribution of vessel score (p = 0.906) and Gensini's score (p = 0.905) were similar in the seropositivity group and seronegativity group of Helicobacter pylori infection. However, the level of fasting high-density lipoprotein cholesterol (mmol/L) (p = 0.013) was significantly lower in the seropositivity group than that in the seronegativity group of Helicobacter pylori infection. CONCLUSIONS: In conclusion, in the present study, a significantly correlation between Helicobacter pylori seropositivity and angiographically evaluated severity of atherosclerosis was not find. And, the present study showed a good correlation between Helicobacter pylori infection and decreased HDL cholesterol. However, the exact mechanisms need further study.
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spelling pubmed-28083012010-01-20 Helicobacter pylori infection is associated with decreased serum levels of high density lipoprotein, but not with the severity of coronary atherosclerosis Jia, En-Zhi Zhao, Fu-Jun Hao, Bo Zhu, Tie-Bing Wang, Lian-Sheng Chen, Bo Cao, Ke-Jiang Huang, Jun Ma, Wen-Zhu Yang, Zhi-Jian Zhang, Guoxin Lipids Health Dis Research OBJECTIVE: The objective of this survey was to study the association between Helicobacter pylori infection and the severity of coronary atherosclerosis. METHODS: The study population consisted of 961 consecutive patients (711 males and 250 females) who underwent coronary angiography for suspected or known coronary atherosclerosis. The patients' body mass index, blood pressure, the blood lipid, blood glucose, leukocyte count (10(9)/L), neutrophil count (10(9)/L), and Helicobacter pylori-specific IgG antibodies were performed. Coronary angiograms were scored according to vessel score and Gensini's score. RESULTS: A significant association between H. pylori infection and coronary atherosclerosis as well as its severity was not find in this cross section study (p = 0.858). And, the level distribution of vessel score (p = 0.906) and Gensini's score (p = 0.905) were similar in the seropositivity group and seronegativity group of Helicobacter pylori infection. However, the level of fasting high-density lipoprotein cholesterol (mmol/L) (p = 0.013) was significantly lower in the seropositivity group than that in the seronegativity group of Helicobacter pylori infection. CONCLUSIONS: In conclusion, in the present study, a significantly correlation between Helicobacter pylori seropositivity and angiographically evaluated severity of atherosclerosis was not find. And, the present study showed a good correlation between Helicobacter pylori infection and decreased HDL cholesterol. However, the exact mechanisms need further study. BioMed Central 2009-12-23 /pmc/articles/PMC2808301/ /pubmed/20030806 http://dx.doi.org/10.1186/1476-511X-8-59 Text en Copyright ©2009 Jia et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Jia, En-Zhi
Zhao, Fu-Jun
Hao, Bo
Zhu, Tie-Bing
Wang, Lian-Sheng
Chen, Bo
Cao, Ke-Jiang
Huang, Jun
Ma, Wen-Zhu
Yang, Zhi-Jian
Zhang, Guoxin
Helicobacter pylori infection is associated with decreased serum levels of high density lipoprotein, but not with the severity of coronary atherosclerosis
title Helicobacter pylori infection is associated with decreased serum levels of high density lipoprotein, but not with the severity of coronary atherosclerosis
title_full Helicobacter pylori infection is associated with decreased serum levels of high density lipoprotein, but not with the severity of coronary atherosclerosis
title_fullStr Helicobacter pylori infection is associated with decreased serum levels of high density lipoprotein, but not with the severity of coronary atherosclerosis
title_full_unstemmed Helicobacter pylori infection is associated with decreased serum levels of high density lipoprotein, but not with the severity of coronary atherosclerosis
title_short Helicobacter pylori infection is associated with decreased serum levels of high density lipoprotein, but not with the severity of coronary atherosclerosis
title_sort helicobacter pylori infection is associated with decreased serum levels of high density lipoprotein, but not with the severity of coronary atherosclerosis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808301/
https://www.ncbi.nlm.nih.gov/pubmed/20030806
http://dx.doi.org/10.1186/1476-511X-8-59
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