Expression of NGF and GDNF family members and their receptors during peripheral nerve development and differentiation of Schwann cells in vitro

Ligands of NGF and GDNF families of neurotrophic factors have important functions in the development of the vertebrate peripheral nervous system (PNS). It has been established that they also play key roles in the regeneration of PNS. Expression patterns of NGF and GDNF family members and their recep...

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Autores principales: Piirsoo, Marko, Kaljas, Anne, Tamm, Karin, Timmusk, Tõnis
Formato: Texto
Lenguaje:English
Publicado: Elsevier Scientific Publishers Ireland 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808476/
https://www.ncbi.nlm.nih.gov/pubmed/19944743
http://dx.doi.org/10.1016/j.neulet.2009.11.060
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author Piirsoo, Marko
Kaljas, Anne
Tamm, Karin
Timmusk, Tõnis
author_facet Piirsoo, Marko
Kaljas, Anne
Tamm, Karin
Timmusk, Tõnis
author_sort Piirsoo, Marko
collection PubMed
description Ligands of NGF and GDNF families of neurotrophic factors have important functions in the development of the vertebrate peripheral nervous system (PNS). It has been established that they also play key roles in the regeneration of PNS. Expression patterns of NGF and GDNF family members and their receptors have mostly been analyzed during regeneration, and less during development of the PNS. We describe the expression of mRNAs encoding these neurotrophic factors and their receptors during development of rat sciatic nerve and in three modes of differentiation of cultured rat Schwann cells. Our results demonstrate specific expression patterns of NGF and GDNF family ligands and their receptors during differentiation of Schwann cells in vivo and in vitro.
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spelling pubmed-28084762010-01-29 Expression of NGF and GDNF family members and their receptors during peripheral nerve development and differentiation of Schwann cells in vitro Piirsoo, Marko Kaljas, Anne Tamm, Karin Timmusk, Tõnis Neurosci Lett Article Ligands of NGF and GDNF families of neurotrophic factors have important functions in the development of the vertebrate peripheral nervous system (PNS). It has been established that they also play key roles in the regeneration of PNS. Expression patterns of NGF and GDNF family members and their receptors have mostly been analyzed during regeneration, and less during development of the PNS. We describe the expression of mRNAs encoding these neurotrophic factors and their receptors during development of rat sciatic nerve and in three modes of differentiation of cultured rat Schwann cells. Our results demonstrate specific expression patterns of NGF and GDNF family ligands and their receptors during differentiation of Schwann cells in vivo and in vitro. Elsevier Scientific Publishers Ireland 2010-01-18 /pmc/articles/PMC2808476/ /pubmed/19944743 http://dx.doi.org/10.1016/j.neulet.2009.11.060 Text en © 2010 Elsevier Ireland Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
Piirsoo, Marko
Kaljas, Anne
Tamm, Karin
Timmusk, Tõnis
Expression of NGF and GDNF family members and their receptors during peripheral nerve development and differentiation of Schwann cells in vitro
title Expression of NGF and GDNF family members and their receptors during peripheral nerve development and differentiation of Schwann cells in vitro
title_full Expression of NGF and GDNF family members and their receptors during peripheral nerve development and differentiation of Schwann cells in vitro
title_fullStr Expression of NGF and GDNF family members and their receptors during peripheral nerve development and differentiation of Schwann cells in vitro
title_full_unstemmed Expression of NGF and GDNF family members and their receptors during peripheral nerve development and differentiation of Schwann cells in vitro
title_short Expression of NGF and GDNF family members and their receptors during peripheral nerve development and differentiation of Schwann cells in vitro
title_sort expression of ngf and gdnf family members and their receptors during peripheral nerve development and differentiation of schwann cells in vitro
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808476/
https://www.ncbi.nlm.nih.gov/pubmed/19944743
http://dx.doi.org/10.1016/j.neulet.2009.11.060
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