The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline

Do prophylactic anticonvulsants decrease the risk of seizure in patients with metastatic brain tumors compared with no treatment? Target population These recommendations apply to adults with solid brain metastases who have not experienced a seizure due to their metastatic brain disease. Recommendati...

Descripción completa

Detalles Bibliográficos
Autores principales: Mikkelsen, Tom, Paleologos, Nina A., Robinson, Paula D., Ammirati, Mario, Andrews, David W., Asher, Anthony L., Burri, Stuart H., Cobbs, Charles S., Gaspar, Laurie E., Kondziolka, Douglas, Linskey, Mark E., Loeffler, Jay S., McDermott, Michael, Mehta, Minesh P., Olson, Jeffrey J., Patchell, Roy A., Ryken, Timothy C., Kalkanis, Steven N.
Formato: Texto
Lenguaje:English
Publicado: Springer US 2009
Materias:
Invited Manuscript
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808526/
https://www.ncbi.nlm.nih.gov/pubmed/19957015
http://dx.doi.org/10.1007/s11060-009-0056-5
Descripción
Sumario:Do prophylactic anticonvulsants decrease the risk of seizure in patients with metastatic brain tumors compared with no treatment? Target population These recommendations apply to adults with solid brain metastases who have not experienced a seizure due to their metastatic brain disease. Recommendation Level 3 For adults with brain metastases who have not experienced a seizure due to their metastatic brain disease, routine prophylactic use of anticonvulsants is not recommended. Only a single underpowered randomized controlled trial (RCT), which did not detect a difference in seizure occurrence, provides evidence for decision-making purposes.

Ejemplares similares