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Nomograms for the Prediction of Pathologic Stage of Clinically Localized Prostate Cancer in Korean Men

We analyzed the prostate cancer data of 317 Korean men with clinically localized prostate cancer who underwent radical prostatectomy at Asan Medical Center between June 1990 and November 2003 to construct nomograms predicting the pathologic stage of these tumors, and compared the outcome with preexi...

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Autores principales: Song, Cheryn, Kang, Taejin, Ro, Jae Y., Lee, Moo-Song, Kim, Choung-Soo, Ahn, Hanjong
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808603/
https://www.ncbi.nlm.nih.gov/pubmed/15831998
http://dx.doi.org/10.3346/jkms.2005.20.2.262
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author Song, Cheryn
Kang, Taejin
Ro, Jae Y.
Lee, Moo-Song
Kim, Choung-Soo
Ahn, Hanjong
author_facet Song, Cheryn
Kang, Taejin
Ro, Jae Y.
Lee, Moo-Song
Kim, Choung-Soo
Ahn, Hanjong
author_sort Song, Cheryn
collection PubMed
description We analyzed the prostate cancer data of 317 Korean men with clinically localized prostate cancer who underwent radical prostatectomy at Asan Medical Center between June 1990 and November 2003 to construct nomograms predicting the pathologic stage of these tumors, and compared the outcome with preexisting nomograms. Multinomial log-linear regression was performed for the simultaneous prediction of organ-confined disease (OCD), extracapsular extension (ECE), seminal vesicle invasion (SVI) and lymph node metastasis (LNM) using serum prostate-specific antigen (PSA), Gleason score and clinical stage. Nomograms representing percent probabilities were constructed and compared with those presented by Partin et al. by calculating areas under the receiver operating characteristics (ROC) curves. Median serum PSA at surgery was 10.8 ng/mL, and median biopsy Gleason score was 7. Overall OCD, ECE, SVI and LNM rates were 59.6%, 20.5%, 11.7% and 8.2%, respectively, and areas under the curves were 0.724, 0.626, 0.662, and 0.794, respectively. Pathologic stage of localized prostate cancer in Korean men may be predicted using the Partin table, with acceptable accuracy for OCD and LNM, but less so for ECE and SVI.
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spelling pubmed-28086032010-01-20 Nomograms for the Prediction of Pathologic Stage of Clinically Localized Prostate Cancer in Korean Men Song, Cheryn Kang, Taejin Ro, Jae Y. Lee, Moo-Song Kim, Choung-Soo Ahn, Hanjong J Korean Med Sci Original Article We analyzed the prostate cancer data of 317 Korean men with clinically localized prostate cancer who underwent radical prostatectomy at Asan Medical Center between June 1990 and November 2003 to construct nomograms predicting the pathologic stage of these tumors, and compared the outcome with preexisting nomograms. Multinomial log-linear regression was performed for the simultaneous prediction of organ-confined disease (OCD), extracapsular extension (ECE), seminal vesicle invasion (SVI) and lymph node metastasis (LNM) using serum prostate-specific antigen (PSA), Gleason score and clinical stage. Nomograms representing percent probabilities were constructed and compared with those presented by Partin et al. by calculating areas under the receiver operating characteristics (ROC) curves. Median serum PSA at surgery was 10.8 ng/mL, and median biopsy Gleason score was 7. Overall OCD, ECE, SVI and LNM rates were 59.6%, 20.5%, 11.7% and 8.2%, respectively, and areas under the curves were 0.724, 0.626, 0.662, and 0.794, respectively. Pathologic stage of localized prostate cancer in Korean men may be predicted using the Partin table, with acceptable accuracy for OCD and LNM, but less so for ECE and SVI. The Korean Academy of Medical Sciences 2005-04 2005-04-30 /pmc/articles/PMC2808603/ /pubmed/15831998 http://dx.doi.org/10.3346/jkms.2005.20.2.262 Text en Copyright © 2005 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Song, Cheryn
Kang, Taejin
Ro, Jae Y.
Lee, Moo-Song
Kim, Choung-Soo
Ahn, Hanjong
Nomograms for the Prediction of Pathologic Stage of Clinically Localized Prostate Cancer in Korean Men
title Nomograms for the Prediction of Pathologic Stage of Clinically Localized Prostate Cancer in Korean Men
title_full Nomograms for the Prediction of Pathologic Stage of Clinically Localized Prostate Cancer in Korean Men
title_fullStr Nomograms for the Prediction of Pathologic Stage of Clinically Localized Prostate Cancer in Korean Men
title_full_unstemmed Nomograms for the Prediction of Pathologic Stage of Clinically Localized Prostate Cancer in Korean Men
title_short Nomograms for the Prediction of Pathologic Stage of Clinically Localized Prostate Cancer in Korean Men
title_sort nomograms for the prediction of pathologic stage of clinically localized prostate cancer in korean men
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808603/
https://www.ncbi.nlm.nih.gov/pubmed/15831998
http://dx.doi.org/10.3346/jkms.2005.20.2.262
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