Analysis of Loss of Heterozygosity in Korean Patients with Keratoacanthoma

Loss of heterozygosity (LOH) has been established as an important genetic mechanism giving rise to malignant neoplasia. The mechanism of LOH has been shown to cause basal cell carcinoma and malignant melanoma as well as other types of skin cancer. A few studies on LOH in sporadic keratoacanthomas ha...

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Autores principales: Ha, Tae-Won, Han, Ki-Hwan, Son, Dae-Gu, Kim, Sang-Pyo, Kim, Dae-Kwang
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2005
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808619/
https://www.ncbi.nlm.nih.gov/pubmed/15832014
http://dx.doi.org/10.3346/jkms.2005.20.2.340
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author Ha, Tae-Won
Han, Ki-Hwan
Son, Dae-Gu
Kim, Sang-Pyo
Kim, Dae-Kwang
author_facet Ha, Tae-Won
Han, Ki-Hwan
Son, Dae-Gu
Kim, Sang-Pyo
Kim, Dae-Kwang
author_sort Ha, Tae-Won
collection PubMed
description Loss of heterozygosity (LOH) has been established as an important genetic mechanism giving rise to malignant neoplasia. The mechanism of LOH has been shown to cause basal cell carcinoma and malignant melanoma as well as other types of skin cancer. A few studies on LOH in sporadic keratoacanthomas have been reported. The purpose of this study was to investigate the significance of LOH in the pathogenesis of sporadic keratoacanthomas developed in 10 Korean patients. The presents of LOH at 7 microsatellite markers (D2S286, D3S1317, D5S346, D9S160, D9S171, D10S185, and D17S261) were evaluated in sporadic keratoacanthomas. LOH was found in only 1 of 10 cases at D10S185. The low frequency of LOH detected in this study suggests that LOH may not be significant in the induction of sporadic keratoacanthomas.
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spelling pubmed-28086192010-01-20 Analysis of Loss of Heterozygosity in Korean Patients with Keratoacanthoma Ha, Tae-Won Han, Ki-Hwan Son, Dae-Gu Kim, Sang-Pyo Kim, Dae-Kwang J Korean Med Sci Brief Communication Loss of heterozygosity (LOH) has been established as an important genetic mechanism giving rise to malignant neoplasia. The mechanism of LOH has been shown to cause basal cell carcinoma and malignant melanoma as well as other types of skin cancer. A few studies on LOH in sporadic keratoacanthomas have been reported. The purpose of this study was to investigate the significance of LOH in the pathogenesis of sporadic keratoacanthomas developed in 10 Korean patients. The presents of LOH at 7 microsatellite markers (D2S286, D3S1317, D5S346, D9S160, D9S171, D10S185, and D17S261) were evaluated in sporadic keratoacanthomas. LOH was found in only 1 of 10 cases at D10S185. The low frequency of LOH detected in this study suggests that LOH may not be significant in the induction of sporadic keratoacanthomas. The Korean Academy of Medical Sciences 2005-04 2005-04-30 /pmc/articles/PMC2808619/ /pubmed/15832014 http://dx.doi.org/10.3346/jkms.2005.20.2.340 Text en Copyright © 2005 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Ha, Tae-Won
Han, Ki-Hwan
Son, Dae-Gu
Kim, Sang-Pyo
Kim, Dae-Kwang
Analysis of Loss of Heterozygosity in Korean Patients with Keratoacanthoma
title Analysis of Loss of Heterozygosity in Korean Patients with Keratoacanthoma
title_full Analysis of Loss of Heterozygosity in Korean Patients with Keratoacanthoma
title_fullStr Analysis of Loss of Heterozygosity in Korean Patients with Keratoacanthoma
title_full_unstemmed Analysis of Loss of Heterozygosity in Korean Patients with Keratoacanthoma
title_short Analysis of Loss of Heterozygosity in Korean Patients with Keratoacanthoma
title_sort analysis of loss of heterozygosity in korean patients with keratoacanthoma
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808619/
https://www.ncbi.nlm.nih.gov/pubmed/15832014
http://dx.doi.org/10.3346/jkms.2005.20.2.340
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