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Sex chromosomes and genetic association studies
Although the literature concerning statistical testing for genotype-phenotype association in family-based and population-based studies is very extensive, until recently the sex chromosomes have received little attention. Here it is shown that the X chromosome in particular presents special problems...
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808745/ https://www.ncbi.nlm.nih.gov/pubmed/19939292 http://dx.doi.org/10.1186/gm110 |
| _version_ | 1782176533912223744 |
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| author | Clayton, David G |
| author_facet | Clayton, David G |
| author_sort | Clayton, David G |
| collection | PubMed |
| description | Although the literature concerning statistical testing for genotype-phenotype association in family-based and population-based studies is very extensive, until recently the sex chromosomes have received little attention. Here it is shown that the X chromosome in particular presents special problems with respect to efficient analysis of mixed-sex population studies, and as a result of X inactivation. This paper reviews recent developments in approaching these problems. |
| format | Text |
| id | pubmed-2808745 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-28087452010-11-24 Sex chromosomes and genetic association studies Clayton, David G Genome Med Review Although the literature concerning statistical testing for genotype-phenotype association in family-based and population-based studies is very extensive, until recently the sex chromosomes have received little attention. Here it is shown that the X chromosome in particular presents special problems with respect to efficient analysis of mixed-sex population studies, and as a result of X inactivation. This paper reviews recent developments in approaching these problems. BioMed Central 2009-11-24 /pmc/articles/PMC2808745/ /pubmed/19939292 http://dx.doi.org/10.1186/gm110 Text en Copyright ©2009 BioMed Central Ltd |
| spellingShingle | Review Clayton, David G Sex chromosomes and genetic association studies |
| title | Sex chromosomes and genetic association studies |
| title_full | Sex chromosomes and genetic association studies |
| title_fullStr | Sex chromosomes and genetic association studies |
| title_full_unstemmed | Sex chromosomes and genetic association studies |
| title_short | Sex chromosomes and genetic association studies |
| title_sort | sex chromosomes and genetic association studies |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808745/ https://www.ncbi.nlm.nih.gov/pubmed/19939292 http://dx.doi.org/10.1186/gm110 |
| work_keys_str_mv | AT claytondavidg sexchromosomesandgeneticassociationstudies |