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Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes
The Network of Cancer Genes (NCG) collects and integrates data on 736 human genes that are mutated in various types of cancer. For each gene, NCG provides information on duplicability, orthology, evolutionary appearance and topological properties of the encoded protein in a comprehensive version of...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Oxford University Press
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808873/ https://www.ncbi.nlm.nih.gov/pubmed/19906700 http://dx.doi.org/10.1093/nar/gkp957 |
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author | Syed, Adnan S. D’Antonio, Matteo Ciccarelli, Francesca D. |
author_facet | Syed, Adnan S. D’Antonio, Matteo Ciccarelli, Francesca D. |
author_sort | Syed, Adnan S. |
collection | PubMed |
description | The Network of Cancer Genes (NCG) collects and integrates data on 736 human genes that are mutated in various types of cancer. For each gene, NCG provides information on duplicability, orthology, evolutionary appearance and topological properties of the encoded protein in a comprehensive version of the human protein-protein interaction network. NCG also stores information on all primary interactors of cancer proteins, thus providing a complete overview of 5357 proteins that constitute direct and indirect determinants of human cancer. With the constant delivery of results from the mutational screenings of cancer genomes, NCG represents a versatile resource for retrieving detailed information on particular cancer genes, as well as for identifying common properties of precompiled lists of cancer genes. NCG is freely available at: http://bio.ifom-ieo-campus.it/ncg. |
format | Text |
id | pubmed-2808873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-28088732010-01-20 Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes Syed, Adnan S. D’Antonio, Matteo Ciccarelli, Francesca D. Nucleic Acids Res Articles The Network of Cancer Genes (NCG) collects and integrates data on 736 human genes that are mutated in various types of cancer. For each gene, NCG provides information on duplicability, orthology, evolutionary appearance and topological properties of the encoded protein in a comprehensive version of the human protein-protein interaction network. NCG also stores information on all primary interactors of cancer proteins, thus providing a complete overview of 5357 proteins that constitute direct and indirect determinants of human cancer. With the constant delivery of results from the mutational screenings of cancer genomes, NCG represents a versatile resource for retrieving detailed information on particular cancer genes, as well as for identifying common properties of precompiled lists of cancer genes. NCG is freely available at: http://bio.ifom-ieo-campus.it/ncg. Oxford University Press 2010-01 2009-11-11 /pmc/articles/PMC2808873/ /pubmed/19906700 http://dx.doi.org/10.1093/nar/gkp957 Text en © The Author(s) 2009. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/2.5/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Syed, Adnan S. D’Antonio, Matteo Ciccarelli, Francesca D. Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes |
title | Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes |
title_full | Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes |
title_fullStr | Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes |
title_full_unstemmed | Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes |
title_short | Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes |
title_sort | network of cancer genes: a web resource to analyze duplicability, orthology and network properties of cancer genes |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808873/ https://www.ncbi.nlm.nih.gov/pubmed/19906700 http://dx.doi.org/10.1093/nar/gkp957 |
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