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AntigenDB: an immunoinformatics database of pathogen antigens

The continuing threat of infectious disease and future pandemics, coupled to the continuous increase of drug-resistant pathogens, makes the discovery of new and better vaccines imperative. For effective vaccine development, antigen discovery and validation is a prerequisite. The compilation of infor...

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Detalles Bibliográficos
Autores principales: Ansari, Hifzur Rahman, Flower, Darren R., Raghava, G. P. S.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808902/
https://www.ncbi.nlm.nih.gov/pubmed/19820110
http://dx.doi.org/10.1093/nar/gkp830
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author Ansari, Hifzur Rahman
Flower, Darren R.
Raghava, G. P. S.
author_facet Ansari, Hifzur Rahman
Flower, Darren R.
Raghava, G. P. S.
author_sort Ansari, Hifzur Rahman
collection PubMed
description The continuing threat of infectious disease and future pandemics, coupled to the continuous increase of drug-resistant pathogens, makes the discovery of new and better vaccines imperative. For effective vaccine development, antigen discovery and validation is a prerequisite. The compilation of information concerning pathogens, virulence factors and antigenic epitopes has resulted in many useful databases. However, most such immunological databases focus almost exclusively on antigens where epitopes are known and ignore those for which epitope information was unavailable. We have compiled more than 500 antigens into the AntigenDB database, making use of the literature and other immunological resources. These antigens come from 44 important pathogenic species. In AntigenDB, a database entry contains information regarding the sequence, structure, origin, etc. of an antigen with additional information such as B and T-cell epitopes, MHC binding, function, gene-expression and post translational modifications, where available. AntigenDB also provides links to major internal and external databases. We shall update AntigenDB on a rolling basis, regularly adding antigens from other organisms and extra data analysis tools. AntigenDB is available freely at http://www.imtech.res.in/raghava/antigendb and its mirror site http://www.bic.uams.edu/raghava/antigendb.
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spelling pubmed-28089022010-01-20 AntigenDB: an immunoinformatics database of pathogen antigens Ansari, Hifzur Rahman Flower, Darren R. Raghava, G. P. S. Nucleic Acids Res Articles The continuing threat of infectious disease and future pandemics, coupled to the continuous increase of drug-resistant pathogens, makes the discovery of new and better vaccines imperative. For effective vaccine development, antigen discovery and validation is a prerequisite. The compilation of information concerning pathogens, virulence factors and antigenic epitopes has resulted in many useful databases. However, most such immunological databases focus almost exclusively on antigens where epitopes are known and ignore those for which epitope information was unavailable. We have compiled more than 500 antigens into the AntigenDB database, making use of the literature and other immunological resources. These antigens come from 44 important pathogenic species. In AntigenDB, a database entry contains information regarding the sequence, structure, origin, etc. of an antigen with additional information such as B and T-cell epitopes, MHC binding, function, gene-expression and post translational modifications, where available. AntigenDB also provides links to major internal and external databases. We shall update AntigenDB on a rolling basis, regularly adding antigens from other organisms and extra data analysis tools. AntigenDB is available freely at http://www.imtech.res.in/raghava/antigendb and its mirror site http://www.bic.uams.edu/raghava/antigendb. Oxford University Press 2010-01 2009-10-09 /pmc/articles/PMC2808902/ /pubmed/19820110 http://dx.doi.org/10.1093/nar/gkp830 Text en © The Author(s) 2009. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/2.5/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Ansari, Hifzur Rahman
Flower, Darren R.
Raghava, G. P. S.
AntigenDB: an immunoinformatics database of pathogen antigens
title AntigenDB: an immunoinformatics database of pathogen antigens
title_full AntigenDB: an immunoinformatics database of pathogen antigens
title_fullStr AntigenDB: an immunoinformatics database of pathogen antigens
title_full_unstemmed AntigenDB: an immunoinformatics database of pathogen antigens
title_short AntigenDB: an immunoinformatics database of pathogen antigens
title_sort antigendb: an immunoinformatics database of pathogen antigens
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808902/
https://www.ncbi.nlm.nih.gov/pubmed/19820110
http://dx.doi.org/10.1093/nar/gkp830
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