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An overview of the PubChem BioAssay resource

The PubChem BioAssay database (http://pubchem.ncbi.nlm.nih.gov) is a public repository for biological activities of small molecules and small interfering RNAs (siRNAs) hosted by the US National Institutes of Health (NIH). It archives experimental descriptions of assays and biological test results an...

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Detalles Bibliográficos
Autores principales: Wang, Yanli, Bolton, Evan, Dracheva, Svetlana, Karapetyan, Karen, Shoemaker, Benjamin A., Suzek, Tugba O., Wang, Jiyao, Xiao, Jewen, Zhang, Jian, Bryant, Stephen H.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808922/
https://www.ncbi.nlm.nih.gov/pubmed/19933261
http://dx.doi.org/10.1093/nar/gkp965
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author Wang, Yanli
Bolton, Evan
Dracheva, Svetlana
Karapetyan, Karen
Shoemaker, Benjamin A.
Suzek, Tugba O.
Wang, Jiyao
Xiao, Jewen
Zhang, Jian
Bryant, Stephen H.
author_facet Wang, Yanli
Bolton, Evan
Dracheva, Svetlana
Karapetyan, Karen
Shoemaker, Benjamin A.
Suzek, Tugba O.
Wang, Jiyao
Xiao, Jewen
Zhang, Jian
Bryant, Stephen H.
author_sort Wang, Yanli
collection PubMed
description The PubChem BioAssay database (http://pubchem.ncbi.nlm.nih.gov) is a public repository for biological activities of small molecules and small interfering RNAs (siRNAs) hosted by the US National Institutes of Health (NIH). It archives experimental descriptions of assays and biological test results and makes the information freely accessible to the public. A PubChem BioAssay data entry includes an assay description, a summary and detailed test results. Each assay record is linked to the molecular target, whenever possible, and is cross-referenced to other National Center for Biotechnology Information (NCBI) database records. ‘Related BioAssays’ are identified by examining the assay target relationship and activity profile of commonly tested compounds. A key goal of PubChem BioAssay is to make the biological activity information easily accessible through the NCBI information retrieval system-Entrez, and various web-based PubChem services. An integrated suite of data analysis tools are available to optimize the utility of the chemical structure and biological activity information within PubChem, enabling researchers to aggregate, compare and analyze biological test results contributed by multiple organizations. In this work, we describe the PubChem BioAssay database, including data model, bioassay deposition and utilities that PubChem provides for searching, downloading and analyzing the biological activity information contained therein.
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spelling pubmed-28089222010-01-20 An overview of the PubChem BioAssay resource Wang, Yanli Bolton, Evan Dracheva, Svetlana Karapetyan, Karen Shoemaker, Benjamin A. Suzek, Tugba O. Wang, Jiyao Xiao, Jewen Zhang, Jian Bryant, Stephen H. Nucleic Acids Res Articles The PubChem BioAssay database (http://pubchem.ncbi.nlm.nih.gov) is a public repository for biological activities of small molecules and small interfering RNAs (siRNAs) hosted by the US National Institutes of Health (NIH). It archives experimental descriptions of assays and biological test results and makes the information freely accessible to the public. A PubChem BioAssay data entry includes an assay description, a summary and detailed test results. Each assay record is linked to the molecular target, whenever possible, and is cross-referenced to other National Center for Biotechnology Information (NCBI) database records. ‘Related BioAssays’ are identified by examining the assay target relationship and activity profile of commonly tested compounds. A key goal of PubChem BioAssay is to make the biological activity information easily accessible through the NCBI information retrieval system-Entrez, and various web-based PubChem services. An integrated suite of data analysis tools are available to optimize the utility of the chemical structure and biological activity information within PubChem, enabling researchers to aggregate, compare and analyze biological test results contributed by multiple organizations. In this work, we describe the PubChem BioAssay database, including data model, bioassay deposition and utilities that PubChem provides for searching, downloading and analyzing the biological activity information contained therein. Oxford University Press 2010-01 2009-11-19 /pmc/articles/PMC2808922/ /pubmed/19933261 http://dx.doi.org/10.1093/nar/gkp965 Text en © Published by Oxford University Press 2009. http://creativecommons.org/licenses/by-nc/2.5/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Wang, Yanli
Bolton, Evan
Dracheva, Svetlana
Karapetyan, Karen
Shoemaker, Benjamin A.
Suzek, Tugba O.
Wang, Jiyao
Xiao, Jewen
Zhang, Jian
Bryant, Stephen H.
An overview of the PubChem BioAssay resource
title An overview of the PubChem BioAssay resource
title_full An overview of the PubChem BioAssay resource
title_fullStr An overview of the PubChem BioAssay resource
title_full_unstemmed An overview of the PubChem BioAssay resource
title_short An overview of the PubChem BioAssay resource
title_sort overview of the pubchem bioassay resource
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808922/
https://www.ncbi.nlm.nih.gov/pubmed/19933261
http://dx.doi.org/10.1093/nar/gkp965
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