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Relationship between carotid intima-media thickness and coronary angiographic findings: a prospective study

BACKGROUND: Since cardiovascular diseases are associated with high mortality and generally undiagnosed before the onset of clinical findings, there is a need for a reliable tool for early diagnosis. Carotid intima-media thickness (CIMT) is a non-invasive marker of coronary artery disease (CAD) and i...

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Autores principales: Coskun, Ugur, Yildiz, Ahmet, Esen, Ozlem B, Baskurt, Murat, Cakar, Mehmet A, Kilickesmez, Kadriye O, Orhan, Lutfu A, Yildiz, Seyma
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809045/
https://www.ncbi.nlm.nih.gov/pubmed/20043836
http://dx.doi.org/10.1186/1476-7120-7-59
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author Coskun, Ugur
Yildiz, Ahmet
Esen, Ozlem B
Baskurt, Murat
Cakar, Mehmet A
Kilickesmez, Kadriye O
Orhan, Lutfu A
Yildiz, Seyma
author_facet Coskun, Ugur
Yildiz, Ahmet
Esen, Ozlem B
Baskurt, Murat
Cakar, Mehmet A
Kilickesmez, Kadriye O
Orhan, Lutfu A
Yildiz, Seyma
author_sort Coskun, Ugur
collection PubMed
description BACKGROUND: Since cardiovascular diseases are associated with high mortality and generally undiagnosed before the onset of clinical findings, there is a need for a reliable tool for early diagnosis. Carotid intima-media thickness (CIMT) is a non-invasive marker of coronary artery disease (CAD) and is widely used in practice as an inexpensive, reliable, and reproducible method. In the current study, we aimed to investigate prospectively the relationship of CIMT with the presence and extent of significant coronary artery narrowing in patients evaluated by coronary angiography for stable angina pectoris. METHODS: One hundred consecutive patients with stable angina pectoris and documented ischemia on a stress test were included in the study. The patients were divided into two groups according to the result of the coronary angiography: group 1 (39 patients) without a noncritical coronary lesion, and group 2 (61 patients) having at least one lesion more than 50% within the main branches of the coronary arteries. All of the patients underwent carotid Doppler ultrasound examination for measurement of the CIMT by a radiologist blinded to the angiographic data. RESULTS: The mean CIMT was 0.78 ± 0.21 mm in Group 1, while it was 1.48 ± 0.28 mm in Group 2 (p = 0.001). The mean CIMT in patients with single vessel disease, multi-vessel disease, and left main coronary artery disease were significantly higher compared to Group 1 (1.2 ± 0.34 mm, p = 0.02; 1.6 ± 0.32 mm, p = 0.001; and 1.8 ± 0.31 mm, p = 0.0001, respectively). Logistic regression analysis identified CIMT (OR 4.3, p < 0.001) and hypertension (OR 2.4, p = 0.04) as the most important factors for predicting CAD. CONCLUSIONS: The findings of this study show that increase in CIMT is associated with the presence and extent of CAD. In conclusion, we demonstrated the usefulness of carotid intima-media thickness in predicting coronary artery disease but large-scale studies are required to define its role in clinical practice.
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spelling pubmed-28090452010-01-21 Relationship between carotid intima-media thickness and coronary angiographic findings: a prospective study Coskun, Ugur Yildiz, Ahmet Esen, Ozlem B Baskurt, Murat Cakar, Mehmet A Kilickesmez, Kadriye O Orhan, Lutfu A Yildiz, Seyma Cardiovasc Ultrasound Research BACKGROUND: Since cardiovascular diseases are associated with high mortality and generally undiagnosed before the onset of clinical findings, there is a need for a reliable tool for early diagnosis. Carotid intima-media thickness (CIMT) is a non-invasive marker of coronary artery disease (CAD) and is widely used in practice as an inexpensive, reliable, and reproducible method. In the current study, we aimed to investigate prospectively the relationship of CIMT with the presence and extent of significant coronary artery narrowing in patients evaluated by coronary angiography for stable angina pectoris. METHODS: One hundred consecutive patients with stable angina pectoris and documented ischemia on a stress test were included in the study. The patients were divided into two groups according to the result of the coronary angiography: group 1 (39 patients) without a noncritical coronary lesion, and group 2 (61 patients) having at least one lesion more than 50% within the main branches of the coronary arteries. All of the patients underwent carotid Doppler ultrasound examination for measurement of the CIMT by a radiologist blinded to the angiographic data. RESULTS: The mean CIMT was 0.78 ± 0.21 mm in Group 1, while it was 1.48 ± 0.28 mm in Group 2 (p = 0.001). The mean CIMT in patients with single vessel disease, multi-vessel disease, and left main coronary artery disease were significantly higher compared to Group 1 (1.2 ± 0.34 mm, p = 0.02; 1.6 ± 0.32 mm, p = 0.001; and 1.8 ± 0.31 mm, p = 0.0001, respectively). Logistic regression analysis identified CIMT (OR 4.3, p < 0.001) and hypertension (OR 2.4, p = 0.04) as the most important factors for predicting CAD. CONCLUSIONS: The findings of this study show that increase in CIMT is associated with the presence and extent of CAD. In conclusion, we demonstrated the usefulness of carotid intima-media thickness in predicting coronary artery disease but large-scale studies are required to define its role in clinical practice. BioMed Central 2009-12-31 /pmc/articles/PMC2809045/ /pubmed/20043836 http://dx.doi.org/10.1186/1476-7120-7-59 Text en Copyright ©2009 Coskun et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Coskun, Ugur
Yildiz, Ahmet
Esen, Ozlem B
Baskurt, Murat
Cakar, Mehmet A
Kilickesmez, Kadriye O
Orhan, Lutfu A
Yildiz, Seyma
Relationship between carotid intima-media thickness and coronary angiographic findings: a prospective study
title Relationship between carotid intima-media thickness and coronary angiographic findings: a prospective study
title_full Relationship between carotid intima-media thickness and coronary angiographic findings: a prospective study
title_fullStr Relationship between carotid intima-media thickness and coronary angiographic findings: a prospective study
title_full_unstemmed Relationship between carotid intima-media thickness and coronary angiographic findings: a prospective study
title_short Relationship between carotid intima-media thickness and coronary angiographic findings: a prospective study
title_sort relationship between carotid intima-media thickness and coronary angiographic findings: a prospective study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809045/
https://www.ncbi.nlm.nih.gov/pubmed/20043836
http://dx.doi.org/10.1186/1476-7120-7-59
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