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Hedgehog Promotes Neovascularization in Pancreatic Cancers by Regulating Ang-1 and IGF-1 Expression in Bone-Marrow Derived Pro-Angiogenic Cells

BACKGROUND: The hedgehog (Hh) pathway has been implicated in the pathogenesis of cancer including pancreatic ductal adenocarcinoma (PDAC). Recent studies have suggested that the oncogenic function of Hh in PDAC involves signaling in the stromal cells rather than cell autonomous effects on the tumor...

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Detalles Bibliográficos
Autores principales:	Nakamura, Kazumasa, Sasajima, Junpei, Mizukami, Yusuke, Sugiyama, Yoshiaki, Yamazaki, Madoka, Fujii, Rie, Kawamoto, Toru, Koizumi, Kazuya, Sato, Kazuya, Fujiya, Mikihiro, Sasaki, Katsunori, Tanno, Satoshi, Okumura, Toshikatsu, Shimizu, Norihiko, Kawabe, Jun-ichi, Karasaki, Hidenori, Kono, Toru, Ii, Masaaki, Bardeesy, Nabeel, Chung, Daniel C., Kohgo, Yutaka
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809097/ https://www.ncbi.nlm.nih.gov/pubmed/20098680 http://dx.doi.org/10.1371/journal.pone.0008824

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