Cargando…

Protein kinase Cα: disease regulator and therapeutic target

Protein kinase Cα (PKCα) is a member of the AGC (which includes PKD, PKG and PKC) family of serine/threonine protein kinases that is widely expressed in mammalian tissues. It is closely related in structure, function and regulation to other members of the protein kinase C family, but has specific fu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Konopatskaya, Olga, Poole, Alastair W.
Formato:	Texto
Lenguaje:	English
Publicado:	Published By Elsevier In Association With The International Union Of Pharmacology 2010
Materias:	Opinion
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809215/ https://www.ncbi.nlm.nih.gov/pubmed/19969380 http://dx.doi.org/10.1016/j.tips.2009.10.006

Ejemplares similares

Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen
por: Gilio, Karen, et al.
Publicado: (2010)

Protein Kinase Cα (PKCα) Regulates Bone Architecture and Osteoblast Activity
por: Galea, Gabriel L., et al.
Publicado: (2014)

Targeting Protein-Protein Interactions to Inhibit Cyclin-Dependent Kinases
por: Klein, Mark
Publicado: (2023)

Dual Regulation of Glycogen Synthase Kinase 3 (GSK3)α/β by Protein Kinase C (PKC)α and Akt Promotes Thrombin-mediated Integrin α(IIb)β(3) Activation and Granule Secretion in Platelets
por: Moore, Samantha F., et al.
Publicado: (2013)

Protein Kinase Cθ Negatively Regulates Store-independent Ca(2+) Entry and Phosphatidylserine Exposure Downstream of Glycoprotein VI in Platelets
por: Harper, Matthew T., et al.
Publicado: (2010)

Targeting of Protein Kinase Cα to Caveolae
por: Mineo, Chieko, et al.
Publicado: (1998)

Genomic analysis of the eukaryotic protein kinase superfamily: a perspective
por: Hanks, Steven K
Publicado: (2003)

Neuropeptide Receptors: Novel Targets for HIV/AIDS Therapeutics
por: Branch, Donald R.
Publicado: (2011)

Dopaminergic Receptor Targeting in Multiple Sclerosis: Is There Therapeutic Potential?
por: Melnikov, Mikhail, et al.
Publicado: (2021)

Therapeutics through glycobiology: an approach for targeted elimination of malaria
por: Divya, Mallya, et al.
Publicado: (2023)

Progress towards mapping the universe of protein folds
por: Grant, Alastair, et al.
Publicado: (2004)

Q&A: targeting autophagy in cancer—a new therapeutic?
por: White, Eileen
Publicado: (2014)

Pumping iron: a potential target for novel therapeutics against schistosomes
por: Glanfield, Amber, et al.
Publicado: (2007)

Targeting the metabolism of leukemia stem cells as a novel therapeutic strategy
por: Ho, Emmanuel A, et al.
Publicado: (2013)

Evidence for a Cross-Talk Between Cytosolic 5′-Nucleotidases and AMP-Activated Protein Kinase
por: Camici, Marcella, et al.
Publicado: (2020)

Preventative and therapeutic vaccination to combat an experimental autoimmune kidney disease
por: Barabas, Arpad Z, et al.
Publicado: (2007)

Therapeutic Potential of Direct Clearance of the Amyloid-β in Alzheimer’s Disease
por: Kim, Dong Eun, et al.
Publicado: (2020)

Shedding light on local kinase activation
por: Scott, John D, et al.
Publicado: (2012)

Breaking out of the citadel: social theory and psychiatry
por: Poole, Rob, et al.
Publicado: (2023)

Use of DAMPs and SAMPs as Therapeutic Targets or Therapeutics: A Note of Caution
por: Land, Walter Gottlieb
Publicado: (2020)

Implications of the obesity epidemic for lipid-lowering therapy: Non-HDL cholesterol should replace LDL cholesterol as the primary therapeutic target
por: Hoenig, Michel R
Publicado: (2008)

How the Glasgow Declaration on Forests can help keep alive the 1.5 °C target
por: Gasser, Thomas, et al.
Publicado: (2022)

Human Ebola virus infection in West Africa: a review of available therapeutic agents that target different steps of the life cycle of Ebola virus
por: Lai, Kang Yiu, et al.
Publicado: (2014)

p53 Protein Isoforms: Key Regulators in the Front Line of Pathogen Infections?
por: Terrier, Olivier, et al.
Publicado: (2013)

Protein kinase C in heart failure: a therapeutic target?
por: Palaniyandi, Suresh Selvaraj, et al.
Publicado: (2009)

The Toxoplasma Kinase ROP18: An Active Member of a Degenerate Family
por: Sinai, Anthony P
Publicado: (2007)

Genetic Analysis of the Role of Protein Kinase Cθ in Platelet Function and Thrombus Formation
por: Hall, Kellie J., et al.
Publicado: (2008)

Role of mitochondria in α-synuclein mediated neuronal toxicity
por: Pai, Sadashiva K.
Publicado: (2023)

Connexin43 in Musculoskeletal System: New Targets for Development and Disease Progression
por: An, Senbo, et al.
Publicado: (2022)

The Mouse Resistance Protein Irgm1 (LRG-47): A Regulator or an Effector of Pathogen Defense?
por: Hunn, Julia P., et al.
Publicado: (2010)

Protein kinase Cα regulates the nucleocytoplasmic shuttling of KRIT1
por: De Luca, Elisa, et al.
Publicado: (2021)

Complement Factors in COVID-19 Therapeutics and Vaccines
por: Kurtovic, Liriye, et al.
Publicado: (2021)

Corticotropin-Releasing Hormone: Biology and Therapeutic Opportunities
por: Caruso, Alessandra, et al.
Publicado: (2022)

Association of diacylglycerol kinase ζ with protein kinase C α: spatial regulation of diacylglycerol signaling
por: Luo, Bai, et al.
Publicado: (2003)

Vpu Matchmakers as a Therapeutic Strategy for HIV Infection
por: Montal, Mauricio
Publicado: (2009)

Zika vaccines and therapeutics: landscape analysis and challenges ahead
por: Wilder-Smith, Annelies, et al.
Publicado: (2018)

Clinical trials to assess adjuvant therapeutics for severe malaria
por: Varo, Rosauro, et al.
Publicado: (2020)

RNA-based therapeutics to treat human fungal infections
por: Bruch, Alexander, et al.
Publicado: (2022)

Hepatitis B Therapeutic Vaccine: A Patent Review
por: Hudu, Shuaibu Abdullahi, et al.
Publicado: (2022)

Open challenges in developing digital therapeutics in the United States
por: Miao, Brenda Y., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2tdg4iv1mvt0v31i6min43rsn3