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The Inflammatory Response to Miniaturised Extracorporeal Circulation: A Review of the Literature
Conventional cardiopulmonary bypass can trigger a systemic inflammatory response syndrome similar to sepsis. Aetiological factors include surgical trauma, reperfusion injury, and, most importantly, contact of the blood with the synthetic surfaces of the heart-lung machine. Recently, a new cardiopulm...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809242/ https://www.ncbi.nlm.nih.gov/pubmed/20101278 http://dx.doi.org/10.1155/2009/707042 |
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author | Vohra, Hunaid A. Whistance, Robert Modi, Amit Ohri, Sunil K. |
author_facet | Vohra, Hunaid A. Whistance, Robert Modi, Amit Ohri, Sunil K. |
author_sort | Vohra, Hunaid A. |
collection | PubMed |
description | Conventional cardiopulmonary bypass can trigger a systemic inflammatory response syndrome similar to sepsis. Aetiological factors include surgical trauma, reperfusion injury, and, most importantly, contact of the blood with the synthetic surfaces of the heart-lung machine. Recently, a new cardiopulmonary bypass system, mini-extracorporeal circulation (MECC), has been developed and has shown promising early results in terms of reducing this inflammatory response. It has no venous reservoir, a reduced priming volume, and less blood-synthetic interface. This review focuses on the inflammatory and clinical outcomes of using MECC and compares these to conventional cardio-pulmonary bypass (CCPB). MECC has been shown to reduce postoperative cytokines levels and other markers of inflammation. In addition, MECC reduces organ damage, postoperative complications and the need for blood transfusion. MECC is a safe and viable perfusion option and in certain circumstances it is superior to CCPB. |
format | Text |
id | pubmed-2809242 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28092422010-01-25 The Inflammatory Response to Miniaturised Extracorporeal Circulation: A Review of the Literature Vohra, Hunaid A. Whistance, Robert Modi, Amit Ohri, Sunil K. Mediators Inflamm Review Article Conventional cardiopulmonary bypass can trigger a systemic inflammatory response syndrome similar to sepsis. Aetiological factors include surgical trauma, reperfusion injury, and, most importantly, contact of the blood with the synthetic surfaces of the heart-lung machine. Recently, a new cardiopulmonary bypass system, mini-extracorporeal circulation (MECC), has been developed and has shown promising early results in terms of reducing this inflammatory response. It has no venous reservoir, a reduced priming volume, and less blood-synthetic interface. This review focuses on the inflammatory and clinical outcomes of using MECC and compares these to conventional cardio-pulmonary bypass (CCPB). MECC has been shown to reduce postoperative cytokines levels and other markers of inflammation. In addition, MECC reduces organ damage, postoperative complications and the need for blood transfusion. MECC is a safe and viable perfusion option and in certain circumstances it is superior to CCPB. Hindawi Publishing Corporation 2009 2010-01-13 /pmc/articles/PMC2809242/ /pubmed/20101278 http://dx.doi.org/10.1155/2009/707042 Text en Copyright © 2009 Hunaid A. Vohra et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Vohra, Hunaid A. Whistance, Robert Modi, Amit Ohri, Sunil K. The Inflammatory Response to Miniaturised Extracorporeal Circulation: A Review of the Literature |
title | The Inflammatory Response to Miniaturised Extracorporeal Circulation: A Review of the Literature |
title_full | The Inflammatory Response to Miniaturised Extracorporeal Circulation: A Review of the Literature |
title_fullStr | The Inflammatory Response to Miniaturised Extracorporeal Circulation: A Review of the Literature |
title_full_unstemmed | The Inflammatory Response to Miniaturised Extracorporeal Circulation: A Review of the Literature |
title_short | The Inflammatory Response to Miniaturised Extracorporeal Circulation: A Review of the Literature |
title_sort | inflammatory response to miniaturised extracorporeal circulation: a review of the literature |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809242/ https://www.ncbi.nlm.nih.gov/pubmed/20101278 http://dx.doi.org/10.1155/2009/707042 |
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