Labile A1C Is Inversely Correlated With the Hemoglobin Glycation Index in Children With Type 1 Diabetes

OBJECTIVE: We hypothesized that labile A1C (LA1C) is directly correlated with stable A1C (SA1C) and between-patient differences in SA1C, which are independent of mean blood glucose (MBG). RESEARCH DESIGN AND METHODS: We measured SA1C, LA1C, MBG, and a single clinic capillary glucose (CCG) from 152 p...

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Detalles Bibliográficos
Autores principales: Chalew, Stuart A., McCarter, Robert J., Ory-Ascani, Jeanine, Hempe, James M.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809262/
https://www.ncbi.nlm.nih.gov/pubmed/19918006
http://dx.doi.org/10.2337/dc08-2220
Descripción
Sumario:OBJECTIVE: We hypothesized that labile A1C (LA1C) is directly correlated with stable A1C (SA1C) and between-patient differences in SA1C, which are independent of mean blood glucose (MBG). RESEARCH DESIGN AND METHODS: We measured SA1C, LA1C, MBG, and a single clinic capillary glucose (CCG) from 152 pediatric patients with type 1 diabetes. Patients were grouped as high, moderate, or low glycators by hemoglobin glycation index (HGI). RESULTS: LA1C and SA1C were correlated with CCG and MBG. LA1C was not correlated with SA1C (r = 0.06, P = 0.453). LA1C level was significantly associated with glycator group status (P < 0.0019) and CCG (P < 0.0001). Adjusted LA1C levels were highest in the low-HGI patients and lowest in the high-HGI group. CONCLUSIONS: A conventional model of SA1C being directly correlated with LA1C concentration was not confirmed. Between-patient differences in SA1C at the same MBG may be due to complex intracellular factors influencing formation of SA1C from LA1C.

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