Cargando…
Inflammation Markers and Metabolic Characteristics of Subjects With 1-h Plasma Glucose Levels
OBJECTIVE: To assess the association of 1-h plasma glucose (1hPG) and inflammation with normal glucose tolerance (NGT) and pre-diabetes. RESEARCH DESIGN AND METHODS: A cohort of 1,062 subjects was enrolled. After oral glucose load (oral glucose tolerance test), we compared subjects with NGT and pre-...
Autores principales: | , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809294/ https://www.ncbi.nlm.nih.gov/pubmed/19918010 http://dx.doi.org/10.2337/dc09-1342 |
_version_ | 1782176606570151936 |
---|---|
author | Bardini, Gianluca Dicembrini, Ilaria Cresci, Barbara Rotella, Carlo Maria |
author_facet | Bardini, Gianluca Dicembrini, Ilaria Cresci, Barbara Rotella, Carlo Maria |
author_sort | Bardini, Gianluca |
collection | PubMed |
description | OBJECTIVE: To assess the association of 1-h plasma glucose (1hPG) and inflammation with normal glucose tolerance (NGT) and pre-diabetes. RESEARCH DESIGN AND METHODS: A cohort of 1,062 subjects was enrolled. After oral glucose load (oral glucose tolerance test), we compared subjects with NGT and pre-diabetes above and below the 1hPG cut point (155 mg/dl). Fibrinogen and leukocytes count (white blood cells [WBCs]) for subclinical inflammation, lipid ratios, insulin sensitivity (Matsuda index) were determined. RESULTS: Patients with NGT and pre-diabetes (1hPG >155 mg/dl) showed a significant increase of inflammatory markers and lipid ratios (for all, P < 0.05). In age-, sex-, and BMI-adjusted analysis, 1hPG was associated with a significantly higher WBC count and fibrinogen (P < 0.05). Patients with elevated 1hPG showed a highly significant lower insulin sensitivity than subjects <1hPG (P < 0.01). CONCLUSIONS: Elevated 1hPG in subjects with NGT and pre-diabetes is associated with subclinical inflammation, high lipid ratios, and insulin resistance. Therefore, 1hPG >155 mg/dl could be considered a new “marker” for cardiovascular risk. |
format | Text |
id | pubmed-2809294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-28092942011-02-01 Inflammation Markers and Metabolic Characteristics of Subjects With 1-h Plasma Glucose Levels Bardini, Gianluca Dicembrini, Ilaria Cresci, Barbara Rotella, Carlo Maria Diabetes Care Original Research OBJECTIVE: To assess the association of 1-h plasma glucose (1hPG) and inflammation with normal glucose tolerance (NGT) and pre-diabetes. RESEARCH DESIGN AND METHODS: A cohort of 1,062 subjects was enrolled. After oral glucose load (oral glucose tolerance test), we compared subjects with NGT and pre-diabetes above and below the 1hPG cut point (155 mg/dl). Fibrinogen and leukocytes count (white blood cells [WBCs]) for subclinical inflammation, lipid ratios, insulin sensitivity (Matsuda index) were determined. RESULTS: Patients with NGT and pre-diabetes (1hPG >155 mg/dl) showed a significant increase of inflammatory markers and lipid ratios (for all, P < 0.05). In age-, sex-, and BMI-adjusted analysis, 1hPG was associated with a significantly higher WBC count and fibrinogen (P < 0.05). Patients with elevated 1hPG showed a highly significant lower insulin sensitivity than subjects <1hPG (P < 0.01). CONCLUSIONS: Elevated 1hPG in subjects with NGT and pre-diabetes is associated with subclinical inflammation, high lipid ratios, and insulin resistance. Therefore, 1hPG >155 mg/dl could be considered a new “marker” for cardiovascular risk. American Diabetes Association 2010-02 2009-11-16 /pmc/articles/PMC2809294/ /pubmed/19918010 http://dx.doi.org/10.2337/dc09-1342 Text en © 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Original Research Bardini, Gianluca Dicembrini, Ilaria Cresci, Barbara Rotella, Carlo Maria Inflammation Markers and Metabolic Characteristics of Subjects With 1-h Plasma Glucose Levels |
title | Inflammation Markers and Metabolic Characteristics of Subjects With 1-h Plasma Glucose Levels |
title_full | Inflammation Markers and Metabolic Characteristics of Subjects With 1-h Plasma Glucose Levels |
title_fullStr | Inflammation Markers and Metabolic Characteristics of Subjects With 1-h Plasma Glucose Levels |
title_full_unstemmed | Inflammation Markers and Metabolic Characteristics of Subjects With 1-h Plasma Glucose Levels |
title_short | Inflammation Markers and Metabolic Characteristics of Subjects With 1-h Plasma Glucose Levels |
title_sort | inflammation markers and metabolic characteristics of subjects with 1-h plasma glucose levels |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809294/ https://www.ncbi.nlm.nih.gov/pubmed/19918010 http://dx.doi.org/10.2337/dc09-1342 |
work_keys_str_mv | AT bardinigianluca inflammationmarkersandmetaboliccharacteristicsofsubjectswith1hplasmaglucoselevels AT dicembriniilaria inflammationmarkersandmetaboliccharacteristicsofsubjectswith1hplasmaglucoselevels AT crescibarbara inflammationmarkersandmetaboliccharacteristicsofsubjectswith1hplasmaglucoselevels AT rotellacarlomaria inflammationmarkersandmetaboliccharacteristicsofsubjectswith1hplasmaglucoselevels |