Cargando…
Current status of 5α-reductase inhibitors in the management of lower urinary tract symptoms and BPH
PURPOSE: Benign prostatic hyperplasia (BPH) is a progressive disease that is commonly associated with bothersome lower urinary tract symptoms (LUTS) and might result in complications, such as acute urinary retention and BPH-related surgery. Therefore, the goals of therapy for BPH are not only to imp...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809314/ https://www.ncbi.nlm.nih.gov/pubmed/19956956 http://dx.doi.org/10.1007/s00345-009-0493-y |
_version_ | 1782176611340124160 |
---|---|
author | Gravas, Stavros Oelke, Matthias |
author_facet | Gravas, Stavros Oelke, Matthias |
author_sort | Gravas, Stavros |
collection | PubMed |
description | PURPOSE: Benign prostatic hyperplasia (BPH) is a progressive disease that is commonly associated with bothersome lower urinary tract symptoms (LUTS) and might result in complications, such as acute urinary retention and BPH-related surgery. Therefore, the goals of therapy for BPH are not only to improve LUTS in terms of symptoms and urinary flow, but also to identify those patients at a risk of unfavorable disease progression and to optimize their management. This article reviews the current status of therapy with 5α-reductase inhibitors (5ARIs), namely fiasteride and dutasteride, for men with LUTS and BPH. METHOD: Data from key randomized controlled trials (Oxford level 1b) on the use of 5ARIs are analyzed. RESULTS: The efficacy of 5ARIs either as monotherapy or in combination with α(1)-adrenoceptor antagonists in the management of LUTS and the impact of monotherapy and combined therapy on BPH progression are discussed. Further promises, including the withdrawal of the α-blocker from the combined medical treatment and the potential clinical implications from the use of 5ARIs for prostate cancer chemoprevention in patients receiving 5ARIs for symptomatic BPH are highlighted. CONCLUSIONS: Current evidence shows that 5ARIs are effective in treating LUTS and preventing disease progression and represent a recommended option in treatment guidelines for men who have moderate to severe LUTS and enlarged prostates. |
format | Text |
id | pubmed-2809314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-28093142010-01-22 Current status of 5α-reductase inhibitors in the management of lower urinary tract symptoms and BPH Gravas, Stavros Oelke, Matthias World J Urol Topic Paper PURPOSE: Benign prostatic hyperplasia (BPH) is a progressive disease that is commonly associated with bothersome lower urinary tract symptoms (LUTS) and might result in complications, such as acute urinary retention and BPH-related surgery. Therefore, the goals of therapy for BPH are not only to improve LUTS in terms of symptoms and urinary flow, but also to identify those patients at a risk of unfavorable disease progression and to optimize their management. This article reviews the current status of therapy with 5α-reductase inhibitors (5ARIs), namely fiasteride and dutasteride, for men with LUTS and BPH. METHOD: Data from key randomized controlled trials (Oxford level 1b) on the use of 5ARIs are analyzed. RESULTS: The efficacy of 5ARIs either as monotherapy or in combination with α(1)-adrenoceptor antagonists in the management of LUTS and the impact of monotherapy and combined therapy on BPH progression are discussed. Further promises, including the withdrawal of the α-blocker from the combined medical treatment and the potential clinical implications from the use of 5ARIs for prostate cancer chemoprevention in patients receiving 5ARIs for symptomatic BPH are highlighted. CONCLUSIONS: Current evidence shows that 5ARIs are effective in treating LUTS and preventing disease progression and represent a recommended option in treatment guidelines for men who have moderate to severe LUTS and enlarged prostates. Springer-Verlag 2009-12-03 2010 /pmc/articles/PMC2809314/ /pubmed/19956956 http://dx.doi.org/10.1007/s00345-009-0493-y Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Topic Paper Gravas, Stavros Oelke, Matthias Current status of 5α-reductase inhibitors in the management of lower urinary tract symptoms and BPH |
title | Current status of 5α-reductase inhibitors in the management of lower urinary tract symptoms and BPH |
title_full | Current status of 5α-reductase inhibitors in the management of lower urinary tract symptoms and BPH |
title_fullStr | Current status of 5α-reductase inhibitors in the management of lower urinary tract symptoms and BPH |
title_full_unstemmed | Current status of 5α-reductase inhibitors in the management of lower urinary tract symptoms and BPH |
title_short | Current status of 5α-reductase inhibitors in the management of lower urinary tract symptoms and BPH |
title_sort | current status of 5α-reductase inhibitors in the management of lower urinary tract symptoms and bph |
topic | Topic Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809314/ https://www.ncbi.nlm.nih.gov/pubmed/19956956 http://dx.doi.org/10.1007/s00345-009-0493-y |
work_keys_str_mv | AT gravasstavros currentstatusof5areductaseinhibitorsinthemanagementoflowerurinarytractsymptomsandbph AT oelkematthias currentstatusof5areductaseinhibitorsinthemanagementoflowerurinarytractsymptomsandbph |