Molecular Mechanisms Involved in Mesenchymal Stem Cell Migration to the Site of Acute Myocardial Infarction

Mesenchymal stem cells or multipotent mesenchymal stromal cells (both referred to as MSC) have been shown in some studies to have a beneficial effect on myocardial recovery after infarct. Current strategies for MSC delivery to heart involve intravenous, intraarterial, and intramuscular delivery. Dif...

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Detalles Bibliográficos
Autores principales: Kollar, Katarina, Cook, Matthew M., Atkinson, Kerry, Brooke, Gary
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809335/
https://www.ncbi.nlm.nih.gov/pubmed/20130773
http://dx.doi.org/10.1155/2009/904682
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author Kollar, Katarina
Cook, Matthew M.
Atkinson, Kerry
Brooke, Gary
author_facet Kollar, Katarina
Cook, Matthew M.
Atkinson, Kerry
Brooke, Gary
author_sort Kollar, Katarina
collection PubMed
description Mesenchymal stem cells or multipotent mesenchymal stromal cells (both referred to as MSC) have been shown in some studies to have a beneficial effect on myocardial recovery after infarct. Current strategies for MSC delivery to heart involve intravenous, intraarterial, and intramuscular delivery. Different routes of MSC delivery and a lack of knowledge of the mechanisms that MSC utilise to migrate in vivo has most likely led to the marked variations in results that have been found. This review aims to summarise the current knowledge of MSC migratory mechanisms and looks to future methods of MSC manipulation prior to delivery in order to enhance MSC migration and engraftment.
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spelling pubmed-28093352010-02-03 Molecular Mechanisms Involved in Mesenchymal Stem Cell Migration to the Site of Acute Myocardial Infarction Kollar, Katarina Cook, Matthew M. Atkinson, Kerry Brooke, Gary Int J Cell Biol Review Article Mesenchymal stem cells or multipotent mesenchymal stromal cells (both referred to as MSC) have been shown in some studies to have a beneficial effect on myocardial recovery after infarct. Current strategies for MSC delivery to heart involve intravenous, intraarterial, and intramuscular delivery. Different routes of MSC delivery and a lack of knowledge of the mechanisms that MSC utilise to migrate in vivo has most likely led to the marked variations in results that have been found. This review aims to summarise the current knowledge of MSC migratory mechanisms and looks to future methods of MSC manipulation prior to delivery in order to enhance MSC migration and engraftment. Hindawi Publishing Corporation 2009 2009-07-12 /pmc/articles/PMC2809335/ /pubmed/20130773 http://dx.doi.org/10.1155/2009/904682 Text en Copyright © 2009 Katarina Kollar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kollar, Katarina
Cook, Matthew M.
Atkinson, Kerry
Brooke, Gary
Molecular Mechanisms Involved in Mesenchymal Stem Cell Migration to the Site of Acute Myocardial Infarction
title Molecular Mechanisms Involved in Mesenchymal Stem Cell Migration to the Site of Acute Myocardial Infarction
title_full Molecular Mechanisms Involved in Mesenchymal Stem Cell Migration to the Site of Acute Myocardial Infarction
title_fullStr Molecular Mechanisms Involved in Mesenchymal Stem Cell Migration to the Site of Acute Myocardial Infarction
title_full_unstemmed Molecular Mechanisms Involved in Mesenchymal Stem Cell Migration to the Site of Acute Myocardial Infarction
title_short Molecular Mechanisms Involved in Mesenchymal Stem Cell Migration to the Site of Acute Myocardial Infarction
title_sort molecular mechanisms involved in mesenchymal stem cell migration to the site of acute myocardial infarction
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809335/
https://www.ncbi.nlm.nih.gov/pubmed/20130773
http://dx.doi.org/10.1155/2009/904682
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