The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels

This study investigated the relationship of children's autism symptoms with their toxic metal body burden and red blood cell (RBC) glutathione levels. In children ages 3–8 years, the severity of autism was assessed using four tools: ADOS, PDD-BI, ATEC, and SAS. Toxic metal body burden was asses...

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Detalles Bibliográficos
Autores principales: Adams, J. B., Baral, M., Geis, E., Mitchell, J., Ingram, J., Hensley, A., Zappia, I., Newmark, S., Gehn, E., Rubin, R. A., Mitchell, K., Bradstreet, J., El-Dahr, J. M.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809421/
https://www.ncbi.nlm.nih.gov/pubmed/20107587
http://dx.doi.org/10.1155/2009/532640
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author Adams, J. B.
Baral, M.
Geis, E.
Mitchell, J.
Ingram, J.
Hensley, A.
Zappia, I.
Newmark, S.
Gehn, E.
Rubin, R. A.
Mitchell, K.
Bradstreet, J.
El-Dahr, J. M.
author_facet Adams, J. B.
Baral, M.
Geis, E.
Mitchell, J.
Ingram, J.
Hensley, A.
Zappia, I.
Newmark, S.
Gehn, E.
Rubin, R. A.
Mitchell, K.
Bradstreet, J.
El-Dahr, J. M.
author_sort Adams, J. B.
collection PubMed
description This study investigated the relationship of children's autism symptoms with their toxic metal body burden and red blood cell (RBC) glutathione levels. In children ages 3–8 years, the severity of autism was assessed using four tools: ADOS, PDD-BI, ATEC, and SAS. Toxic metal body burden was assessed by measuring urinary excretion of toxic metals, both before and after oral dimercaptosuccinic acid (DMSA). Multiple positive correlations were found between the severity of autism and the urinary excretion of toxic metals. Variations in the severity of autism measurements could be explained, in part, by regression analyses of urinary excretion of toxic metals before and after DMSA and the level of RBC glutathione (adjusted R (2) of 0.22–0.45, P < .005 in all cases). This study demonstrates a significant positive association between the severity of autism and the relative body burden of toxic metals.
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spelling pubmed-28094212010-01-27 The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels Adams, J. B. Baral, M. Geis, E. Mitchell, J. Ingram, J. Hensley, A. Zappia, I. Newmark, S. Gehn, E. Rubin, R. A. Mitchell, K. Bradstreet, J. El-Dahr, J. M. J Toxicol Research Article This study investigated the relationship of children's autism symptoms with their toxic metal body burden and red blood cell (RBC) glutathione levels. In children ages 3–8 years, the severity of autism was assessed using four tools: ADOS, PDD-BI, ATEC, and SAS. Toxic metal body burden was assessed by measuring urinary excretion of toxic metals, both before and after oral dimercaptosuccinic acid (DMSA). Multiple positive correlations were found between the severity of autism and the urinary excretion of toxic metals. Variations in the severity of autism measurements could be explained, in part, by regression analyses of urinary excretion of toxic metals before and after DMSA and the level of RBC glutathione (adjusted R (2) of 0.22–0.45, P < .005 in all cases). This study demonstrates a significant positive association between the severity of autism and the relative body burden of toxic metals. Hindawi Publishing Corporation 2009 2009-08-26 /pmc/articles/PMC2809421/ /pubmed/20107587 http://dx.doi.org/10.1155/2009/532640 Text en Copyright © 2009 J. B. Adams et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Adams, J. B.
Baral, M.
Geis, E.
Mitchell, J.
Ingram, J.
Hensley, A.
Zappia, I.
Newmark, S.
Gehn, E.
Rubin, R. A.
Mitchell, K.
Bradstreet, J.
El-Dahr, J. M.
The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels
title The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels
title_full The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels
title_fullStr The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels
title_full_unstemmed The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels
title_short The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels
title_sort severity of autism is associated with toxic metal body burden and red blood cell glutathione levels
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809421/
https://www.ncbi.nlm.nih.gov/pubmed/20107587
http://dx.doi.org/10.1155/2009/532640
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