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Developmental and Reproductive Effects of SE5-OH: An Equol-Rich Soy-Based Ingredient

Consumption of the isoflavones daidzein, genistein, glycitein, and their structural analogues is generally considered beneficial to human health. Equol is not found in soy, but is converted from daidzein by human gut bacterial flora. Research indicates that between 30–50% of the population is capabl...

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Autores principales: Matulka, Ray A., Matsuura, Ikuo, Uesugi, Tohru, Ueno, Tomomi, Burdock, George
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809433/
https://www.ncbi.nlm.nih.gov/pubmed/20107584
http://dx.doi.org/10.1155/2009/307618
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author Matulka, Ray A.
Matsuura, Ikuo
Uesugi, Tohru
Ueno, Tomomi
Burdock, George
author_facet Matulka, Ray A.
Matsuura, Ikuo
Uesugi, Tohru
Ueno, Tomomi
Burdock, George
author_sort Matulka, Ray A.
collection PubMed
description Consumption of the isoflavones daidzein, genistein, glycitein, and their structural analogues is generally considered beneficial to human health. Equol is not found in soy, but is converted from daidzein by human gut bacterial flora. Research indicates that between 30–50% of the population is capable of converting daidzein to equol; therefore, there has been recent development of a new equol-rich functional food that relies on bacterial conversion of daidzein to equol under strictly controlled conditions. Therefore, a new equol-rich soy product (SE5-OH) has been developed, based on the bacterial conversion of daidzein; and its reproductive and developmental toxicity has been evaluated in a two-generation study and a developmental toxicity study with Sprague-Dawley rats at dose levels of 200, 1000, and 2000 mg/kg/day by gavage. SE5-OH contains approximately 0.65% equol, 0.024% daidzein, 0.022% genistein, and 0.30% glycitein. From the reproductive study, the no-observed-adverse-effect-level (NOAEL) for SE5-OH determined for both male and female rats is 1000 mg/kg/day (6.5 mg equol/kg/day). In the developmental toxicity phase of the study, no effects by SE5-OH were found in the embryo-fetus at any of the doses tested. The NOAEL for developmental effects of SE5-OH is 2000 mg/kg/day (13 mg equol/kg/day).
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spelling pubmed-28094332010-01-27 Developmental and Reproductive Effects of SE5-OH: An Equol-Rich Soy-Based Ingredient Matulka, Ray A. Matsuura, Ikuo Uesugi, Tohru Ueno, Tomomi Burdock, George J Toxicol Research Article Consumption of the isoflavones daidzein, genistein, glycitein, and their structural analogues is generally considered beneficial to human health. Equol is not found in soy, but is converted from daidzein by human gut bacterial flora. Research indicates that between 30–50% of the population is capable of converting daidzein to equol; therefore, there has been recent development of a new equol-rich functional food that relies on bacterial conversion of daidzein to equol under strictly controlled conditions. Therefore, a new equol-rich soy product (SE5-OH) has been developed, based on the bacterial conversion of daidzein; and its reproductive and developmental toxicity has been evaluated in a two-generation study and a developmental toxicity study with Sprague-Dawley rats at dose levels of 200, 1000, and 2000 mg/kg/day by gavage. SE5-OH contains approximately 0.65% equol, 0.024% daidzein, 0.022% genistein, and 0.30% glycitein. From the reproductive study, the no-observed-adverse-effect-level (NOAEL) for SE5-OH determined for both male and female rats is 1000 mg/kg/day (6.5 mg equol/kg/day). In the developmental toxicity phase of the study, no effects by SE5-OH were found in the embryo-fetus at any of the doses tested. The NOAEL for developmental effects of SE5-OH is 2000 mg/kg/day (13 mg equol/kg/day). Hindawi Publishing Corporation 2009 2008-12-15 /pmc/articles/PMC2809433/ /pubmed/20107584 http://dx.doi.org/10.1155/2009/307618 Text en Copyright © 2009 Ray A. Matulka et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Matulka, Ray A.
Matsuura, Ikuo
Uesugi, Tohru
Ueno, Tomomi
Burdock, George
Developmental and Reproductive Effects of SE5-OH: An Equol-Rich Soy-Based Ingredient
title Developmental and Reproductive Effects of SE5-OH: An Equol-Rich Soy-Based Ingredient
title_full Developmental and Reproductive Effects of SE5-OH: An Equol-Rich Soy-Based Ingredient
title_fullStr Developmental and Reproductive Effects of SE5-OH: An Equol-Rich Soy-Based Ingredient
title_full_unstemmed Developmental and Reproductive Effects of SE5-OH: An Equol-Rich Soy-Based Ingredient
title_short Developmental and Reproductive Effects of SE5-OH: An Equol-Rich Soy-Based Ingredient
title_sort developmental and reproductive effects of se5-oh: an equol-rich soy-based ingredient
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809433/
https://www.ncbi.nlm.nih.gov/pubmed/20107584
http://dx.doi.org/10.1155/2009/307618
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