Protease-Sensitive Synthetic Prions

Prions arise when the cellular prion protein (PrP(C)) undergoes a self-propagating conformational change; the resulting infectious conformer is designated PrP(Sc). Frequently, PrP(Sc) is protease-resistant but protease-sensitive (s) prions have been isolated in humans and other animals. We report he...

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Detalles Bibliográficos
Autores principales: Colby, David W., Wain, Rachel, Baskakov, Ilia V., Legname, Giuseppe, Palmer, Christina G., Nguyen, Hoang-Oanh B., Lemus, Azucena, Cohen, Fred E., DeArmond, Stephen J., Prusiner, Stanley B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809756/
https://www.ncbi.nlm.nih.gov/pubmed/20107515
http://dx.doi.org/10.1371/journal.ppat.1000736

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