BRIT1/MCPH1 Is Essential for Mitotic and Meiotic Recombination DNA Repair and Maintaining Genomic Stability in Mice

BRIT1 protein (also known as MCPH1) contains 3 BRCT domains which are conserved in BRCA1, BRCA2, and other important molecules involved in DNA damage signaling, DNA repair, and tumor suppression. BRIT1 mutations or aberrant expression are found in primary microcephaly patients as well as in cancer p...

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Detalles Bibliográficos
Autores principales: Liang, Yulong, Gao, Hong, Lin, Shiaw-Yih, Peng, Guang, Huang, Xingxu, Zhang, Pumin, Goss, John A., Brunicardi, Francis C., Multani, Asha S., Chang, Sandy, Li, Kaiyi
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809772/
https://www.ncbi.nlm.nih.gov/pubmed/20107607
http://dx.doi.org/10.1371/journal.pgen.1000826

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