Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons

OBJECTIVE: The sites of insulin action in the central nervous system that regulate glucose metabolism and energy expenditure are incompletely characterized. We have shown that mice with hypothalamic deficiency (L1) of insulin receptors (InsRs) fail to regulate hepatic glucose production (HGP) in res...

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Detalles Bibliográficos
Autores principales: Lin, Hua V., Plum, Leona, Ono, Hiraku, Gutiérrez-Juárez, Roger, Shanabrough, Marya, Borok, Erzsebet, Horvath, Tamas L., Rossetti, Luciano, Accili, Domenico
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809966/
https://www.ncbi.nlm.nih.gov/pubmed/19933998
http://dx.doi.org/10.2337/db09-1303

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