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Estimation of Tegaserod Maleate by Differential Pulse Polarography
A highly sensitive differential pulse polarographic method has been developed for the estimation of tegaserod maleate after treating it with hydrogen peroxide solution. The oxidation of tegaserod maleate is a reversible process as the oxidized product could be reduced at hanging mercury drop electro...
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810048/ https://www.ncbi.nlm.nih.gov/pubmed/20177456 http://dx.doi.org/10.4103/0250-474X.51956 |
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author | Rajput, S. J. Raj, H. A. |
author_facet | Rajput, S. J. Raj, H. A. |
author_sort | Rajput, S. J. |
collection | PubMed |
description | A highly sensitive differential pulse polarographic method has been developed for the estimation of tegaserod maleate after treating it with hydrogen peroxide solution. The oxidation of tegaserod maleate is a reversible process as the oxidized product could be reduced at hanging mercury drop electrode in a quantitative manner using differential pulse polarography mode. The limit of quantification was 0.1ng/ml. The voltametric peak was obtained at -1.05 volts in presence of 0.1M potassium chloride as supporting electrolyte. The technique could be used successfully to analyze tegaserod maleate in its tablet formulation. |
format | Text |
id | pubmed-2810048 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-28100482010-02-22 Estimation of Tegaserod Maleate by Differential Pulse Polarography Rajput, S. J. Raj, H. A. Indian J Pharm Sci Short Communication A highly sensitive differential pulse polarographic method has been developed for the estimation of tegaserod maleate after treating it with hydrogen peroxide solution. The oxidation of tegaserod maleate is a reversible process as the oxidized product could be reduced at hanging mercury drop electrode in a quantitative manner using differential pulse polarography mode. The limit of quantification was 0.1ng/ml. The voltametric peak was obtained at -1.05 volts in presence of 0.1M potassium chloride as supporting electrolyte. The technique could be used successfully to analyze tegaserod maleate in its tablet formulation. Medknow Publications 2009 /pmc/articles/PMC2810048/ /pubmed/20177456 http://dx.doi.org/10.4103/0250-474X.51956 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Rajput, S. J. Raj, H. A. Estimation of Tegaserod Maleate by Differential Pulse Polarography |
title | Estimation of Tegaserod Maleate by Differential Pulse Polarography |
title_full | Estimation of Tegaserod Maleate by Differential Pulse Polarography |
title_fullStr | Estimation of Tegaserod Maleate by Differential Pulse Polarography |
title_full_unstemmed | Estimation of Tegaserod Maleate by Differential Pulse Polarography |
title_short | Estimation of Tegaserod Maleate by Differential Pulse Polarography |
title_sort | estimation of tegaserod maleate by differential pulse polarography |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810048/ https://www.ncbi.nlm.nih.gov/pubmed/20177456 http://dx.doi.org/10.4103/0250-474X.51956 |
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