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Spectrophotometric Estimation of Ketotifen Fumarate from Tablet Formulations
Two simple and sensitive visible spectrophotometric methods have been developed for the quantitative estimation of ketotifen fumarate from its tablet formulation. The developed methods are based on formation of chloroform extractable colored complex of with 2-nitroso- napthol-4- sulphonic acid and r...
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810054/ https://www.ncbi.nlm.nih.gov/pubmed/20177462 http://dx.doi.org/10.4103/0250-474X.51964 |
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author | Singhvi, I. Sachdeva, D. |
author_facet | Singhvi, I. Sachdeva, D. |
author_sort | Singhvi, I. |
collection | PubMed |
description | Two simple and sensitive visible spectrophotometric methods have been developed for the quantitative estimation of ketotifen fumarate from its tablet formulation. The developed methods are based on formation of chloroform extractable colored complex of with 2-nitroso- napthol-4- sulphonic acid and rhodizonic acid. The extracted complex of drug with 2-nitroso- napthol-4- sulphonic acid (method-I), showed absorbance maxima at 436.5 nm and with rhodizonic acid (method-II), showed absorbance maxima at 489.5 nm. The linearity range for both the developed methods was observed in the concentration range of 50-250 µg/ml of drug. Results of analysis for both the developed methods were validated statistically and by recovery studies. |
format | Text |
id | pubmed-2810054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-28100542010-02-22 Spectrophotometric Estimation of Ketotifen Fumarate from Tablet Formulations Singhvi, I. Sachdeva, D. Indian J Pharm Sci Short Communication Two simple and sensitive visible spectrophotometric methods have been developed for the quantitative estimation of ketotifen fumarate from its tablet formulation. The developed methods are based on formation of chloroform extractable colored complex of with 2-nitroso- napthol-4- sulphonic acid and rhodizonic acid. The extracted complex of drug with 2-nitroso- napthol-4- sulphonic acid (method-I), showed absorbance maxima at 436.5 nm and with rhodizonic acid (method-II), showed absorbance maxima at 489.5 nm. The linearity range for both the developed methods was observed in the concentration range of 50-250 µg/ml of drug. Results of analysis for both the developed methods were validated statistically and by recovery studies. Medknow Publications 2009 /pmc/articles/PMC2810054/ /pubmed/20177462 http://dx.doi.org/10.4103/0250-474X.51964 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Singhvi, I. Sachdeva, D. Spectrophotometric Estimation of Ketotifen Fumarate from Tablet Formulations |
title | Spectrophotometric Estimation of Ketotifen Fumarate from Tablet Formulations |
title_full | Spectrophotometric Estimation of Ketotifen Fumarate from Tablet Formulations |
title_fullStr | Spectrophotometric Estimation of Ketotifen Fumarate from Tablet Formulations |
title_full_unstemmed | Spectrophotometric Estimation of Ketotifen Fumarate from Tablet Formulations |
title_short | Spectrophotometric Estimation of Ketotifen Fumarate from Tablet Formulations |
title_sort | spectrophotometric estimation of ketotifen fumarate from tablet formulations |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810054/ https://www.ncbi.nlm.nih.gov/pubmed/20177462 http://dx.doi.org/10.4103/0250-474X.51964 |
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