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Topical Delivery of Flurbiprofen from Pluronic Lecithin Organogel

The purpose of this research is to formulate and evaluate the suitability of pluronic lecithin organogels containing flurbiprofen for topical application. Four formulations were developed using flurbiprofen, lecithin, Pluronic F127, isopropyl palmitate, water, sorbic acid and potassium sorbate were...

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Detalles Bibliográficos
Autores principales: Pandey, M. S., Belgamwar, V. S., Surana, S. J.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810062/
https://www.ncbi.nlm.nih.gov/pubmed/20177469
http://dx.doi.org/10.4103/0250-474X.51955
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author Pandey, M. S.
Belgamwar, V. S.
Surana, S. J.
author_facet Pandey, M. S.
Belgamwar, V. S.
Surana, S. J.
author_sort Pandey, M. S.
collection PubMed
description The purpose of this research is to formulate and evaluate the suitability of pluronic lecithin organogels containing flurbiprofen for topical application. Four formulations were developed using flurbiprofen, lecithin, Pluronic F127, isopropyl palmitate, water, sorbic acid and potassium sorbate were coded as FL1, FL2, FL3 and FL4. All the formulations carried 30% w/w of lecithin phase and 70% w/w of Pluronic phase. The formulated organogels were evaluated for appearance and feel psychorheologically, in vitro diffusion study, drug content, viscosity and pH. Release of flurbiprofen from all formulations was monitored via dialysis membrane-70 and Wistar rat skin as a semipermeable membrane into phosphate buffer saline (0.2 M, pH 7.4) using Keshary-Chien diffusion cell. The viscosities of different formulations were determined by using Brookfield Viscometer at 25°. An attempt has been made to explore the potential of pluronic lecithin organogels for topical delivery of flurbiprofen.
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spelling pubmed-28100622010-02-22 Topical Delivery of Flurbiprofen from Pluronic Lecithin Organogel Pandey, M. S. Belgamwar, V. S. Surana, S. J. Indian J Pharm Sci Short Communication The purpose of this research is to formulate and evaluate the suitability of pluronic lecithin organogels containing flurbiprofen for topical application. Four formulations were developed using flurbiprofen, lecithin, Pluronic F127, isopropyl palmitate, water, sorbic acid and potassium sorbate were coded as FL1, FL2, FL3 and FL4. All the formulations carried 30% w/w of lecithin phase and 70% w/w of Pluronic phase. The formulated organogels were evaluated for appearance and feel psychorheologically, in vitro diffusion study, drug content, viscosity and pH. Release of flurbiprofen from all formulations was monitored via dialysis membrane-70 and Wistar rat skin as a semipermeable membrane into phosphate buffer saline (0.2 M, pH 7.4) using Keshary-Chien diffusion cell. The viscosities of different formulations were determined by using Brookfield Viscometer at 25°. An attempt has been made to explore the potential of pluronic lecithin organogels for topical delivery of flurbiprofen. Medknow Publications 2009 /pmc/articles/PMC2810062/ /pubmed/20177469 http://dx.doi.org/10.4103/0250-474X.51955 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Pandey, M. S.
Belgamwar, V. S.
Surana, S. J.
Topical Delivery of Flurbiprofen from Pluronic Lecithin Organogel
title Topical Delivery of Flurbiprofen from Pluronic Lecithin Organogel
title_full Topical Delivery of Flurbiprofen from Pluronic Lecithin Organogel
title_fullStr Topical Delivery of Flurbiprofen from Pluronic Lecithin Organogel
title_full_unstemmed Topical Delivery of Flurbiprofen from Pluronic Lecithin Organogel
title_short Topical Delivery of Flurbiprofen from Pluronic Lecithin Organogel
title_sort topical delivery of flurbiprofen from pluronic lecithin organogel
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810062/
https://www.ncbi.nlm.nih.gov/pubmed/20177469
http://dx.doi.org/10.4103/0250-474X.51955
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