Synthesis and Antimicrobial Activity of 5-Imidazolinone Derivatives

Several 4-arylidene-2-phenyl-1-(2,4,5-trichlorophenyl)-1H-imidazol-5(4H)-ones (4a-q), N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-4-chlorobenzamides (5a-o) and N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-2,4-dichlorobenzamides (6a-m) were prepared. All newly synthesized c...

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Detalles Bibliográficos
Autores principales: Desai, N. C., Bhavsar, A. M., Baldaniya, B. B.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810063/
https://www.ncbi.nlm.nih.gov/pubmed/20177470
http://dx.doi.org/10.4103/0250-474X.51953
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author Desai, N. C.
Bhavsar, A. M.
Baldaniya, B. B.
author_facet Desai, N. C.
Bhavsar, A. M.
Baldaniya, B. B.
author_sort Desai, N. C.
collection PubMed
description Several 4-arylidene-2-phenyl-1-(2,4,5-trichlorophenyl)-1H-imidazol-5(4H)-ones (4a-q), N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-4-chlorobenzamides (5a-o) and N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-2,4-dichlorobenzamides (6a-m) were prepared. All newly synthesized compounds have been tested for their antibacterial activity against gram (+)ve and gram (−)ve bacteria and also on different strains of fungi. Introduction of OH, OCH(3), NO(2), Cl and Br groups to the heterocyclic frame work enhanced antibacterial and antifungal activities.
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spelling pubmed-28100632010-02-22 Synthesis and Antimicrobial Activity of 5-Imidazolinone Derivatives Desai, N. C. Bhavsar, A. M. Baldaniya, B. B. Indian J Pharm Sci Short Communication Several 4-arylidene-2-phenyl-1-(2,4,5-trichlorophenyl)-1H-imidazol-5(4H)-ones (4a-q), N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-4-chlorobenzamides (5a-o) and N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-2,4-dichlorobenzamides (6a-m) were prepared. All newly synthesized compounds have been tested for their antibacterial activity against gram (+)ve and gram (−)ve bacteria and also on different strains of fungi. Introduction of OH, OCH(3), NO(2), Cl and Br groups to the heterocyclic frame work enhanced antibacterial and antifungal activities. Medknow Publications 2009 /pmc/articles/PMC2810063/ /pubmed/20177470 http://dx.doi.org/10.4103/0250-474X.51953 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Desai, N. C.
Bhavsar, A. M.
Baldaniya, B. B.
Synthesis and Antimicrobial Activity of 5-Imidazolinone Derivatives
title Synthesis and Antimicrobial Activity of 5-Imidazolinone Derivatives
title_full Synthesis and Antimicrobial Activity of 5-Imidazolinone Derivatives
title_fullStr Synthesis and Antimicrobial Activity of 5-Imidazolinone Derivatives
title_full_unstemmed Synthesis and Antimicrobial Activity of 5-Imidazolinone Derivatives
title_short Synthesis and Antimicrobial Activity of 5-Imidazolinone Derivatives
title_sort synthesis and antimicrobial activity of 5-imidazolinone derivatives
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810063/
https://www.ncbi.nlm.nih.gov/pubmed/20177470
http://dx.doi.org/10.4103/0250-474X.51953
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