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Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity

In spite of the high abundance and species diversity of diatoms, only a few bioactive compounds from them have been described. The present study reveals a high number of mammalian cell death inducing substances in biofilm-associated diatoms sampled from the intertidal zone. Extracts from the genera...

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Autores principales: Prestegard, Siv Kristin, Oftedal, Linn, Coyne, Rosie Theresa, Nygaard, Gyrid, Skjærven, Kaja Helvik, Knutsen, Gjert, Døskeland, Stein Ove, Herfindal, Lars
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810217/
https://www.ncbi.nlm.nih.gov/pubmed/20098602
http://dx.doi.org/10.3390/md7040605
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author Prestegard, Siv Kristin
Oftedal, Linn
Coyne, Rosie Theresa
Nygaard, Gyrid
Skjærven, Kaja Helvik
Knutsen, Gjert
Døskeland, Stein Ove
Herfindal, Lars
author_facet Prestegard, Siv Kristin
Oftedal, Linn
Coyne, Rosie Theresa
Nygaard, Gyrid
Skjærven, Kaja Helvik
Knutsen, Gjert
Døskeland, Stein Ove
Herfindal, Lars
author_sort Prestegard, Siv Kristin
collection PubMed
description In spite of the high abundance and species diversity of diatoms, only a few bioactive compounds from them have been described. The present study reveals a high number of mammalian cell death inducing substances in biofilm-associated diatoms sampled from the intertidal zone. Extracts from the genera Melosira, Amphora, Phaeodactylum and Nitzschia were all found to induce leukemia cell death, with either classical apoptotic or autophagic features. Several extracts also contained inhibitors of thrombin-induced blood platelet activation. Some of this activity was caused by a high content of adenosine in the diatoms, ranging from 0.07 to 0.31 μg/mg dry weight. However, most of the bioactivity was adenosine deaminase-resistant. An adenosine deaminase-resistant active fraction from one of the extracts was partially purified and shown to induce apoptosis with a distinct phenotype. The results show that benthic diatoms typically found in the intertidal zone may represent a richer source of interesting bioactive compounds than hitherto recognized.
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spelling pubmed-28102172010-01-22 Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity Prestegard, Siv Kristin Oftedal, Linn Coyne, Rosie Theresa Nygaard, Gyrid Skjærven, Kaja Helvik Knutsen, Gjert Døskeland, Stein Ove Herfindal, Lars Mar Drugs Article In spite of the high abundance and species diversity of diatoms, only a few bioactive compounds from them have been described. The present study reveals a high number of mammalian cell death inducing substances in biofilm-associated diatoms sampled from the intertidal zone. Extracts from the genera Melosira, Amphora, Phaeodactylum and Nitzschia were all found to induce leukemia cell death, with either classical apoptotic or autophagic features. Several extracts also contained inhibitors of thrombin-induced blood platelet activation. Some of this activity was caused by a high content of adenosine in the diatoms, ranging from 0.07 to 0.31 μg/mg dry weight. However, most of the bioactivity was adenosine deaminase-resistant. An adenosine deaminase-resistant active fraction from one of the extracts was partially purified and shown to induce apoptosis with a distinct phenotype. The results show that benthic diatoms typically found in the intertidal zone may represent a richer source of interesting bioactive compounds than hitherto recognized. Molecular Diversity Preservation International 2009-11-18 /pmc/articles/PMC2810217/ /pubmed/20098602 http://dx.doi.org/10.3390/md7040605 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Prestegard, Siv Kristin
Oftedal, Linn
Coyne, Rosie Theresa
Nygaard, Gyrid
Skjærven, Kaja Helvik
Knutsen, Gjert
Døskeland, Stein Ove
Herfindal, Lars
Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity
title Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity
title_full Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity
title_fullStr Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity
title_full_unstemmed Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity
title_short Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity
title_sort marine benthic diatoms contain compounds able to induce leukemia cell death and modulate blood platelet activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810217/
https://www.ncbi.nlm.nih.gov/pubmed/20098602
http://dx.doi.org/10.3390/md7040605
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