Microarray-Based Transcriptional Profiling of Renieramycin M and Jorunnamycin C, Isolated from Thai Marine Organisms

Renieramycin M and jorunnamycin C, two isoquinolinequinone compounds differing only at the C-22 ester side chain, were evaluated for their cytotoxic effects on human colon (HCT116) and breast (MDA-MB-435) cancer cell lines. These two compounds displayed potent cancer cell growth inhibition, their IC...

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Autores principales: Charupant, Kornvika, Suwanborirux, Khanit, Daikuhara, Naomi, Yokoya, Masashi, Ushijima-Sugano, Rie, Kawai, Takatoshi, Owa, Takashi, Saito, Naoki
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810219/
https://www.ncbi.nlm.nih.gov/pubmed/20098592
http://dx.doi.org/10.3390/md7040483
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author Charupant, Kornvika
Suwanborirux, Khanit
Daikuhara, Naomi
Yokoya, Masashi
Ushijima-Sugano, Rie
Kawai, Takatoshi
Owa, Takashi
Saito, Naoki
author_facet Charupant, Kornvika
Suwanborirux, Khanit
Daikuhara, Naomi
Yokoya, Masashi
Ushijima-Sugano, Rie
Kawai, Takatoshi
Owa, Takashi
Saito, Naoki
author_sort Charupant, Kornvika
collection PubMed
description Renieramycin M and jorunnamycin C, two isoquinolinequinone compounds differing only at the C-22 ester side chain, were evaluated for their cytotoxic effects on human colon (HCT116) and breast (MDA-MB-435) cancer cell lines. These two compounds displayed potent cancer cell growth inhibition, their IC(50) values reaching nanomolar order. To examine their effects on transcription, we carried out oligonucleotide microarray analysis with focus on the similarities and differences between the two compounds in terms of transcriptional profiles. We found that the down-regulation of PTPRK (protein tyrosine phosphatase receptor type K) can be considered as a biomarker responsive to the cytotoxic effects of this class of antitumor marine natural products.
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spelling pubmed-28102192010-01-22 Microarray-Based Transcriptional Profiling of Renieramycin M and Jorunnamycin C, Isolated from Thai Marine Organisms Charupant, Kornvika Suwanborirux, Khanit Daikuhara, Naomi Yokoya, Masashi Ushijima-Sugano, Rie Kawai, Takatoshi Owa, Takashi Saito, Naoki Mar Drugs Communication Renieramycin M and jorunnamycin C, two isoquinolinequinone compounds differing only at the C-22 ester side chain, were evaluated for their cytotoxic effects on human colon (HCT116) and breast (MDA-MB-435) cancer cell lines. These two compounds displayed potent cancer cell growth inhibition, their IC(50) values reaching nanomolar order. To examine their effects on transcription, we carried out oligonucleotide microarray analysis with focus on the similarities and differences between the two compounds in terms of transcriptional profiles. We found that the down-regulation of PTPRK (protein tyrosine phosphatase receptor type K) can be considered as a biomarker responsive to the cytotoxic effects of this class of antitumor marine natural products. Molecular Diversity Preservation International 2009-10-19 /pmc/articles/PMC2810219/ /pubmed/20098592 http://dx.doi.org/10.3390/md7040483 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Charupant, Kornvika
Suwanborirux, Khanit
Daikuhara, Naomi
Yokoya, Masashi
Ushijima-Sugano, Rie
Kawai, Takatoshi
Owa, Takashi
Saito, Naoki
Microarray-Based Transcriptional Profiling of Renieramycin M and Jorunnamycin C, Isolated from Thai Marine Organisms
title Microarray-Based Transcriptional Profiling of Renieramycin M and Jorunnamycin C, Isolated from Thai Marine Organisms
title_full Microarray-Based Transcriptional Profiling of Renieramycin M and Jorunnamycin C, Isolated from Thai Marine Organisms
title_fullStr Microarray-Based Transcriptional Profiling of Renieramycin M and Jorunnamycin C, Isolated from Thai Marine Organisms
title_full_unstemmed Microarray-Based Transcriptional Profiling of Renieramycin M and Jorunnamycin C, Isolated from Thai Marine Organisms
title_short Microarray-Based Transcriptional Profiling of Renieramycin M and Jorunnamycin C, Isolated from Thai Marine Organisms
title_sort microarray-based transcriptional profiling of renieramycin m and jorunnamycin c, isolated from thai marine organisms
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810219/
https://www.ncbi.nlm.nih.gov/pubmed/20098592
http://dx.doi.org/10.3390/md7040483
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