Isolation of C(11) Cyclopentenones from Two Didemnid Species, Lissoclinum sp. and Diplosoma sp.

A series of new C(11) cyclopentenones 1–7 was isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp. The other didemnid ascidian Diplosoma sp. contained didemnenones 1, 2 and 5, and five known metabolites 8–12. The structures of 1–7...

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Detalles Bibliográficos
Autores principales: Ogi, Takayuki, Margiastuti, Palupi, Teruya, Toshiaki, Taira, Junsei, Suenaga, Kiyotake, Ueda, Katsuhiro
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810228/
https://www.ncbi.nlm.nih.gov/pubmed/20098612
http://dx.doi.org/10.3390/md7040816
Descripción
Sumario:A series of new C(11) cyclopentenones 1–7 was isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp. The other didemnid ascidian Diplosoma sp. contained didemnenones 1, 2 and 5, and five known metabolites 8–12. The structures of 1–7 were elucidated by spectroscopic analyses. Cytotoxicity of the isolated compounds was evaluated against three human cancer cell lines (HCT116, A431 and A549).

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