Generation of Knockout Rats with X-Linked Severe Combined Immunodeficiency (X-SCID) Using Zinc-Finger Nucleases

BACKGROUND: Although the rat is extensively used as a laboratory model, the inability to utilize germ line-competent rat embryonic stem (ES) cells has been a major drawback for studies that aim to elucidate gene functions. Recently, zinc-finger nucleases (ZFNs) were successfully used to create genom...

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Detalles Bibliográficos
Autores principales: Mashimo, Tomoji, Takizawa, Akiko, Voigt, Birger, Yoshimi, Kazuto, Hiai, Hiroshi, Kuramoto, Takashi, Serikawa, Tadao
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810328/
https://www.ncbi.nlm.nih.gov/pubmed/20111598
http://dx.doi.org/10.1371/journal.pone.0008870

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