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Dialysis-associated peritonitis in children

Peritonitis remains a frequent complication of peritoneal dialysis in children and is the most common reason for technique failure. The microbiology is characterized by a predominance of Gram-positive organisms, with fungi responsible for less than 5% of episodes. Data collected by the International...

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Detalles Bibliográficos
Autores principales: Chadha, Vimal, Schaefer, Franz S., Warady, Bradley A.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810362/
https://www.ncbi.nlm.nih.gov/pubmed/19190935
http://dx.doi.org/10.1007/s00467-008-1113-6
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author Chadha, Vimal
Schaefer, Franz S.
Warady, Bradley A.
author_facet Chadha, Vimal
Schaefer, Franz S.
Warady, Bradley A.
author_sort Chadha, Vimal
collection PubMed
description Peritonitis remains a frequent complication of peritoneal dialysis in children and is the most common reason for technique failure. The microbiology is characterized by a predominance of Gram-positive organisms, with fungi responsible for less than 5% of episodes. Data collected by the International Pediatric Peritonitis Registry have revealed a worldwide variation in the bacterial etiology of peritonitis, as well as in the rate of culture-negative peritonitis. Risk factors for infection include young age, the absence of prophylactic antibiotics at catheter placement, spiking of dialysis bags, and the presence of a catheter exit-site or tunnel infection. Clinical symptoms at presentation are somewhat organism specific and can be objectively assessed with a Disease Severity Score. Whereas recommendations for empiric antibiotic therapy in children have been published by the International Society of Peritoneal Dialysis, epidemiologic data and antibiotic susceptibility data suggest that it may be desirable to take the patient- and center-specific history of microorganisms and their sensitivity patterns into account when prescribing initial therapy. The vast majority of patients are treated successfully and continue peritoneal dialysis, with the poorest outcome noted in patients with peritonitis secondary to Gram-negative organisms or fungi and in those with a relapsing infection.
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spelling pubmed-28103622010-01-29 Dialysis-associated peritonitis in children Chadha, Vimal Schaefer, Franz S. Warady, Bradley A. Pediatr Nephrol Educational Review Peritonitis remains a frequent complication of peritoneal dialysis in children and is the most common reason for technique failure. The microbiology is characterized by a predominance of Gram-positive organisms, with fungi responsible for less than 5% of episodes. Data collected by the International Pediatric Peritonitis Registry have revealed a worldwide variation in the bacterial etiology of peritonitis, as well as in the rate of culture-negative peritonitis. Risk factors for infection include young age, the absence of prophylactic antibiotics at catheter placement, spiking of dialysis bags, and the presence of a catheter exit-site or tunnel infection. Clinical symptoms at presentation are somewhat organism specific and can be objectively assessed with a Disease Severity Score. Whereas recommendations for empiric antibiotic therapy in children have been published by the International Society of Peritoneal Dialysis, epidemiologic data and antibiotic susceptibility data suggest that it may be desirable to take the patient- and center-specific history of microorganisms and their sensitivity patterns into account when prescribing initial therapy. The vast majority of patients are treated successfully and continue peritoneal dialysis, with the poorest outcome noted in patients with peritonitis secondary to Gram-negative organisms or fungi and in those with a relapsing infection. Springer-Verlag 2009-02-04 2010-03 /pmc/articles/PMC2810362/ /pubmed/19190935 http://dx.doi.org/10.1007/s00467-008-1113-6 Text en © IPNA 2009
spellingShingle Educational Review
Chadha, Vimal
Schaefer, Franz S.
Warady, Bradley A.
Dialysis-associated peritonitis in children
title Dialysis-associated peritonitis in children
title_full Dialysis-associated peritonitis in children
title_fullStr Dialysis-associated peritonitis in children
title_full_unstemmed Dialysis-associated peritonitis in children
title_short Dialysis-associated peritonitis in children
title_sort dialysis-associated peritonitis in children
topic Educational Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810362/
https://www.ncbi.nlm.nih.gov/pubmed/19190935
http://dx.doi.org/10.1007/s00467-008-1113-6
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