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Architecture of the RNA polymerase II–TFIIF complex revealed by cross-linking and mass spectrometry
Higher-order multi-protein complexes such as RNA polymerase II (Pol II) complexes with transcription initiation factors are often not amenable to X-ray structure determination. Here, we show that protein cross-linking coupled to mass spectrometry (MS) has now sufficiently advanced as a tool to exten...
Autores principales: | , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810376/ https://www.ncbi.nlm.nih.gov/pubmed/20094031 http://dx.doi.org/10.1038/emboj.2009.401 |