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Identification of Compounds That Inhibit IGF-I Signaling in Hyperglycemia

Increased responsiveness of vascular cells to the growth factor IGF-I has been implicated in complications associated with diabetes. Here we describe the development of an assay and screening of a library of compounds for their ability to accelerate cleavage of the transmembrane protein integrin-ass...

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Detalles Bibliográficos
Autores principales:	Maile, Laura A., Allen, Lee B., Veluvolu, Umadevi, Capps, Byron E., Busby, Walker H., Rowland, Michael, Clemmons, David R.
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810469/ https://www.ncbi.nlm.nih.gov/pubmed/20111736 http://dx.doi.org/10.1155/2009/267107

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