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OXIDATIVE STRESS IN EXPERIMENTAL VITILIGO C57BL/6 MICE
AIM: To evaluate whether oxidative stress is implicated in melanocyte damage in vitiligo. BACKGROUND: Vitiligo is a complex disorder characterized by gradually enlarging areas of depigmentation. A new unifying hypothesis for the etiology of this pigment disorder is proposed, in which we postulate th...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810685/ https://www.ncbi.nlm.nih.gov/pubmed/20161850 http://dx.doi.org/10.4103/0019-5154.55628 |
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author | Jalel, Akrem Yassine, Mrabet Hamdaoui, Mohamed Hédi |
author_facet | Jalel, Akrem Yassine, Mrabet Hamdaoui, Mohamed Hédi |
author_sort | Jalel, Akrem |
collection | PubMed |
description | AIM: To evaluate whether oxidative stress is implicated in melanocyte damage in vitiligo. BACKGROUND: Vitiligo is a complex disorder characterized by gradually enlarging areas of depigmentation. A new unifying hypothesis for the etiology of this pigment disorder is proposed, in which we postulate that the final destruction of melanocytes in vitiligo results from a cascade of reactions initiated by a disregulation of melanogenesis, as the result of a breakdown in free radical defense. METHODS: We evaluated 18 vitiligo mice and 12 controls that were age matched. Parameters of oxidative stress such as catalase (CAT), superoxide dismutase (SOD), and plasma malondialdehyde (MDA) were measured by spectrophotometry. RESULTS: MDA levels in vitiligo mice were significantly higher than in controls (P < 0.001). CAT, SOD, and glutathione peroxidase (GPx) activities in mice were significantly lower than controls (P < 0.05 and P < 0.001, respectively). CONCLUSION: Our results confirmed that oxidative stress plays an important role in the pathogenesis of vitiligo. Melanocyte damage in vitiligo might be linked to generalized oxidative stress. This study is the first report on antioxidant parameters in experimental vitiligo mice. |
format | Text |
id | pubmed-2810685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-28106852010-02-16 OXIDATIVE STRESS IN EXPERIMENTAL VITILIGO C57BL/6 MICE Jalel, Akrem Yassine, Mrabet Hamdaoui, Mohamed Hédi Indian J Dermatol Basic Research AIM: To evaluate whether oxidative stress is implicated in melanocyte damage in vitiligo. BACKGROUND: Vitiligo is a complex disorder characterized by gradually enlarging areas of depigmentation. A new unifying hypothesis for the etiology of this pigment disorder is proposed, in which we postulate that the final destruction of melanocytes in vitiligo results from a cascade of reactions initiated by a disregulation of melanogenesis, as the result of a breakdown in free radical defense. METHODS: We evaluated 18 vitiligo mice and 12 controls that were age matched. Parameters of oxidative stress such as catalase (CAT), superoxide dismutase (SOD), and plasma malondialdehyde (MDA) were measured by spectrophotometry. RESULTS: MDA levels in vitiligo mice were significantly higher than in controls (P < 0.001). CAT, SOD, and glutathione peroxidase (GPx) activities in mice were significantly lower than controls (P < 0.05 and P < 0.001, respectively). CONCLUSION: Our results confirmed that oxidative stress plays an important role in the pathogenesis of vitiligo. Melanocyte damage in vitiligo might be linked to generalized oxidative stress. This study is the first report on antioxidant parameters in experimental vitiligo mice. Medknow Publications 2009 /pmc/articles/PMC2810685/ /pubmed/20161850 http://dx.doi.org/10.4103/0019-5154.55628 Text en © Indian Journal of Dermatology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Basic Research Jalel, Akrem Yassine, Mrabet Hamdaoui, Mohamed Hédi OXIDATIVE STRESS IN EXPERIMENTAL VITILIGO C57BL/6 MICE |
title | OXIDATIVE STRESS IN EXPERIMENTAL VITILIGO C57BL/6 MICE |
title_full | OXIDATIVE STRESS IN EXPERIMENTAL VITILIGO C57BL/6 MICE |
title_fullStr | OXIDATIVE STRESS IN EXPERIMENTAL VITILIGO C57BL/6 MICE |
title_full_unstemmed | OXIDATIVE STRESS IN EXPERIMENTAL VITILIGO C57BL/6 MICE |
title_short | OXIDATIVE STRESS IN EXPERIMENTAL VITILIGO C57BL/6 MICE |
title_sort | oxidative stress in experimental vitiligo c57bl/6 mice |
topic | Basic Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810685/ https://www.ncbi.nlm.nih.gov/pubmed/20161850 http://dx.doi.org/10.4103/0019-5154.55628 |
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