Binding of the human nucleotide excision repair proteins XPA and XPC/HR23B to the 5R-thymine glycol lesion and structure of the cis-(5R,6S) thymine glycol epimer in the 5′-GTgG-3′ sequence: destabilization of two base pairs at the lesion site

The 5R thymine glycol (5R-Tg) DNA lesion exists as a mixture of cis-(5R,6S) and trans-(5R,6R) epimers; these modulate base excision repair. We examine the 7:3 cis-(5R,6S):trans-(5R,6R) mixture of epimers paired opposite adenine in the 5′-GTgG-3′ sequence with regard to nucleotide excision repair. Hu...

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Detalles Bibliográficos
Autores principales: Brown, Kyle L., Roginskaya, Marina, Zou, Yue, Altamirano, Alvin, Basu, Ashis K., Stone, Michael P.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811006/
https://www.ncbi.nlm.nih.gov/pubmed/19892827
http://dx.doi.org/10.1093/nar/gkp844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811006/
https://www.ncbi.nlm.nih.gov/pubmed/19892827
http://dx.doi.org/10.1093/nar/gkp844

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