A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G(2)/M DNA Damage Checkpoint

DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to survive genotoxic insults depends not only on the initiation of cell cycle checkpoints but also on checkpoint maintenance. While activation of DNA damage checkpoints has been studied extensively, molecular...

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Detalles Bibliográficos
Autores principales: van Vugt, Marcel A. T. M., Gardino, Alexandra K., Linding, Rune, Ostheimer, Gerard J., Reinhardt, H. Christian, Ong, Shao-En, Tan, Chris S., Miao, Hua, Keezer, Susan M., Li, Jeijin, Pawson, Tony, Lewis, Timothy A., Carr, Steven A., Smerdon, Stephen J., Brummelkamp, Thijn R., Yaffe, Michael B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811157/
https://www.ncbi.nlm.nih.gov/pubmed/20126263
http://dx.doi.org/10.1371/journal.pbio.1000287

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