Interlaboratory Development and Validation of a HRM Method Applied to the Detection of JAK2 Exon 12 Mutations in Polycythemia Vera Patients

BACKGROUND: Myeloproliferative disorders are characterized by clonal expansion of normal mature blood cells. Acquired mutations giving rise to constitutive activation of the JAK2 tyrosine kinase has been shown to be present in the majority of patients. Since the demonstration that the V617F mutation...

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Detalles Bibliográficos
Autores principales: Ugo, Valerie, Tondeur, Sylvie, Menot, Marie-Laurence, Bonnin, Nadine, Le Gac, Gerald, Tonetti, Carole, Mas, Veronique Mansat-De, Lecucq, Lydie, Kiladjian, Jean-Jacques, Chomienne, Christine, Dosquet, Christine, Parquet, Nathalie, Darnige, Luc, Porneuf, Marc, Escoffre-Barbe, Martine, Giraudier, Stephane, Delabesse, Eric, Cassinat, Bruno
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811183/
https://www.ncbi.nlm.nih.gov/pubmed/20126644
http://dx.doi.org/10.1371/journal.pone.0008893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811183/
https://www.ncbi.nlm.nih.gov/pubmed/20126644
http://dx.doi.org/10.1371/journal.pone.0008893

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