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Alpha-1,2-Mannosidase and Hence N-Glycosylation Are Required for Regulatory T Cell Migration and Allograft Tolerance in Mice

BACKGROUND: Specific immunological unresponsiveness to alloantigens can be induced in vivo by treating mice with a donor alloantigen in combination with a non-depleting anti-CD4 antibody. This tolerance induction protocol enriches for alloantigen reactive regulatory T cells (Treg). We previously dem...

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Detalles Bibliográficos
Autores principales: Long, Elaine T., Baker, Stephanie, Oliveira, Vanessa, Sawitzki, Birgit, Wood, Kathryn J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811199/
https://www.ncbi.nlm.nih.gov/pubmed/20126660
http://dx.doi.org/10.1371/journal.pone.0008894