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Genetic Correlation of Community-Associated Methicillin-Resistant Staphylococcus aureus Strains from Carriers and from Patients with Clinical Infection in One Region of Korea
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is an increasingly common worldwide and colonizing S. aureus strains may serve as the causative pathogen for overt clinical infections. This study was performed to determine whether the pathogenic CA-MRSA isolate in clinical in...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Academy of Medical Sciences
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811284/ https://www.ncbi.nlm.nih.gov/pubmed/20119570 http://dx.doi.org/10.3346/jkms.2010.25.2.197 |
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author | Bae, In-Gyu Kim, Jae Seok Kim, Sunjoo Heo, Sang Taek Chang, Chulhun Lee, Eun-Yup |
author_facet | Bae, In-Gyu Kim, Jae Seok Kim, Sunjoo Heo, Sang Taek Chang, Chulhun Lee, Eun-Yup |
author_sort | Bae, In-Gyu |
collection | PubMed |
description | Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is an increasingly common worldwide and colonizing S. aureus strains may serve as the causative pathogen for overt clinical infections. This study was performed to determine whether the pathogenic CA-MRSA isolate in clinical infections was genetically related to the MRSA isolates in community carriers. We prospectively collected a total of 42 CA-MRSA isolates (23 clinical infection isolates and 19 colonization isolates) in a local region of Korea. Antimicrobial susceptibility tests, staphylococcal toxin assays, SCCmec typing, multilocus sequence typing (MLST), and spa (staphylococcal protein A) typing were performed with all isolates. Thirty-four (81%) of 42 CA-MRSA isolates belonged to sequence type (ST) 72 in the MLST analysis. The distribution of STs did not differ significantly between colonization and clinical infection isolates (89.5% [17/19] vs. 73.9% [17/23], P=0.26). Among the ST72-MRSA isolates, spa type t664 (18, 52.9%) and t324 (8, 23.5%) were common in both groups. This study demonstrates that the community-associated MRSA strains from patients with clinical infections are closely related to the strains found in carriers from one local community. |
format | Text |
id | pubmed-2811284 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-28112842010-02-01 Genetic Correlation of Community-Associated Methicillin-Resistant Staphylococcus aureus Strains from Carriers and from Patients with Clinical Infection in One Region of Korea Bae, In-Gyu Kim, Jae Seok Kim, Sunjoo Heo, Sang Taek Chang, Chulhun Lee, Eun-Yup J Korean Med Sci Original Article Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is an increasingly common worldwide and colonizing S. aureus strains may serve as the causative pathogen for overt clinical infections. This study was performed to determine whether the pathogenic CA-MRSA isolate in clinical infections was genetically related to the MRSA isolates in community carriers. We prospectively collected a total of 42 CA-MRSA isolates (23 clinical infection isolates and 19 colonization isolates) in a local region of Korea. Antimicrobial susceptibility tests, staphylococcal toxin assays, SCCmec typing, multilocus sequence typing (MLST), and spa (staphylococcal protein A) typing were performed with all isolates. Thirty-four (81%) of 42 CA-MRSA isolates belonged to sequence type (ST) 72 in the MLST analysis. The distribution of STs did not differ significantly between colonization and clinical infection isolates (89.5% [17/19] vs. 73.9% [17/23], P=0.26). Among the ST72-MRSA isolates, spa type t664 (18, 52.9%) and t324 (8, 23.5%) were common in both groups. This study demonstrates that the community-associated MRSA strains from patients with clinical infections are closely related to the strains found in carriers from one local community. The Korean Academy of Medical Sciences 2010-02 2010-01-21 /pmc/articles/PMC2811284/ /pubmed/20119570 http://dx.doi.org/10.3346/jkms.2010.25.2.197 Text en © 2010 The Korean Academy of Medical Sciences. http://jkms.org/index.php?main=terms This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0 (http://jkms.org/index.php?main=terms) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Bae, In-Gyu Kim, Jae Seok Kim, Sunjoo Heo, Sang Taek Chang, Chulhun Lee, Eun-Yup Genetic Correlation of Community-Associated Methicillin-Resistant Staphylococcus aureus Strains from Carriers and from Patients with Clinical Infection in One Region of Korea |
title | Genetic Correlation of Community-Associated Methicillin-Resistant Staphylococcus aureus Strains from Carriers and from Patients with Clinical Infection in One Region of Korea |
title_full | Genetic Correlation of Community-Associated Methicillin-Resistant Staphylococcus aureus Strains from Carriers and from Patients with Clinical Infection in One Region of Korea |
title_fullStr | Genetic Correlation of Community-Associated Methicillin-Resistant Staphylococcus aureus Strains from Carriers and from Patients with Clinical Infection in One Region of Korea |
title_full_unstemmed | Genetic Correlation of Community-Associated Methicillin-Resistant Staphylococcus aureus Strains from Carriers and from Patients with Clinical Infection in One Region of Korea |
title_short | Genetic Correlation of Community-Associated Methicillin-Resistant Staphylococcus aureus Strains from Carriers and from Patients with Clinical Infection in One Region of Korea |
title_sort | genetic correlation of community-associated methicillin-resistant staphylococcus aureus strains from carriers and from patients with clinical infection in one region of korea |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811284/ https://www.ncbi.nlm.nih.gov/pubmed/20119570 http://dx.doi.org/10.3346/jkms.2010.25.2.197 |
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