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Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations

The hepatitis B virus (HBV) polymerase gene has overlapping reading frames with surface genes, which allows to alter the amino acid codon of the surface genes. In adefovir (ADV) treated chronic hepatitis B patients carrying rtA181T/rtA181V mutations, overlap with surface gene mutations such as sW172...

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Autores principales: Kim, Jeong Han, Jung, Young Kul, Joo, Moon Kyung, Kim, Ji Hoon, Yim, Hyung Joon, Park, Jong-Jae, Kim, Jae Seon, Bak, Young-Tae, Yeon, Jong Eun, Byun, Kwan Soo
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811294/
https://www.ncbi.nlm.nih.gov/pubmed/20119580
http://dx.doi.org/10.3346/jkms.2010.25.2.257
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author Kim, Jeong Han
Jung, Young Kul
Joo, Moon Kyung
Kim, Ji Hoon
Yim, Hyung Joon
Park, Jong-Jae
Kim, Jae Seon
Bak, Young-Tae
Yeon, Jong Eun
Byun, Kwan Soo
author_facet Kim, Jeong Han
Jung, Young Kul
Joo, Moon Kyung
Kim, Ji Hoon
Yim, Hyung Joon
Park, Jong-Jae
Kim, Jae Seon
Bak, Young-Tae
Yeon, Jong Eun
Byun, Kwan Soo
author_sort Kim, Jeong Han
collection PubMed
description The hepatitis B virus (HBV) polymerase gene has overlapping reading frames with surface genes, which allows to alter the amino acid codon of the surface genes. In adefovir (ADV) treated chronic hepatitis B patients carrying rtA181T/rtA181V mutations, overlap with surface gene mutations such as sW172stop/sL173F has been reported. However, the clinical consequences of such surface mutations have not been determined. The aim of this study was to determine the surface gene sequence in ADV-resistant patients carrying the A181T/V mutation and to describe the clinical significance. Of the 22 patients included in this study, 13 were ADV-resistant with rtA181T/V mutations (polymerase mutation group, Group P) and nine were antiviral treatment-naïve (control group, Group C). The Pre-S1 gene mutation, V60A, was detected in 11 patients (Group P=8, Group C=3). A start codon mutation in the Pre-S2 gene was found in five patients (Group P=3, Group C=2). An S gene mutation, sA184V, was found in nine patients, all of whom were in group P. Although sW172stop and sL173F mutations were detected, reduced HBsAg titer was not observed. Further study of these mutations and their clinical implications are needed.
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spelling pubmed-28112942010-02-01 Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations Kim, Jeong Han Jung, Young Kul Joo, Moon Kyung Kim, Ji Hoon Yim, Hyung Joon Park, Jong-Jae Kim, Jae Seon Bak, Young-Tae Yeon, Jong Eun Byun, Kwan Soo J Korean Med Sci Original Article The hepatitis B virus (HBV) polymerase gene has overlapping reading frames with surface genes, which allows to alter the amino acid codon of the surface genes. In adefovir (ADV) treated chronic hepatitis B patients carrying rtA181T/rtA181V mutations, overlap with surface gene mutations such as sW172stop/sL173F has been reported. However, the clinical consequences of such surface mutations have not been determined. The aim of this study was to determine the surface gene sequence in ADV-resistant patients carrying the A181T/V mutation and to describe the clinical significance. Of the 22 patients included in this study, 13 were ADV-resistant with rtA181T/V mutations (polymerase mutation group, Group P) and nine were antiviral treatment-naïve (control group, Group C). The Pre-S1 gene mutation, V60A, was detected in 11 patients (Group P=8, Group C=3). A start codon mutation in the Pre-S2 gene was found in five patients (Group P=3, Group C=2). An S gene mutation, sA184V, was found in nine patients, all of whom were in group P. Although sW172stop and sL173F mutations were detected, reduced HBsAg titer was not observed. Further study of these mutations and their clinical implications are needed. The Korean Academy of Medical Sciences 2010-02 2009-01-19 /pmc/articles/PMC2811294/ /pubmed/20119580 http://dx.doi.org/10.3346/jkms.2010.25.2.257 Text en © 2010 The Korean Academy of Medical Sciences. http://jkms.org/index.php?main=terms This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0 (http://jkms.org/index.php?main=terms) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Jeong Han
Jung, Young Kul
Joo, Moon Kyung
Kim, Ji Hoon
Yim, Hyung Joon
Park, Jong-Jae
Kim, Jae Seon
Bak, Young-Tae
Yeon, Jong Eun
Byun, Kwan Soo
Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations
title Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations
title_full Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations
title_fullStr Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations
title_full_unstemmed Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations
title_short Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations
title_sort hepatitis b viral surface mutations in patients with adefovir resistant chronic hepatitis b with a181t/v polymerase mutations
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811294/
https://www.ncbi.nlm.nih.gov/pubmed/20119580
http://dx.doi.org/10.3346/jkms.2010.25.2.257
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