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Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations
The hepatitis B virus (HBV) polymerase gene has overlapping reading frames with surface genes, which allows to alter the amino acid codon of the surface genes. In adefovir (ADV) treated chronic hepatitis B patients carrying rtA181T/rtA181V mutations, overlap with surface gene mutations such as sW172...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Academy of Medical Sciences
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811294/ https://www.ncbi.nlm.nih.gov/pubmed/20119580 http://dx.doi.org/10.3346/jkms.2010.25.2.257 |
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author | Kim, Jeong Han Jung, Young Kul Joo, Moon Kyung Kim, Ji Hoon Yim, Hyung Joon Park, Jong-Jae Kim, Jae Seon Bak, Young-Tae Yeon, Jong Eun Byun, Kwan Soo |
author_facet | Kim, Jeong Han Jung, Young Kul Joo, Moon Kyung Kim, Ji Hoon Yim, Hyung Joon Park, Jong-Jae Kim, Jae Seon Bak, Young-Tae Yeon, Jong Eun Byun, Kwan Soo |
author_sort | Kim, Jeong Han |
collection | PubMed |
description | The hepatitis B virus (HBV) polymerase gene has overlapping reading frames with surface genes, which allows to alter the amino acid codon of the surface genes. In adefovir (ADV) treated chronic hepatitis B patients carrying rtA181T/rtA181V mutations, overlap with surface gene mutations such as sW172stop/sL173F has been reported. However, the clinical consequences of such surface mutations have not been determined. The aim of this study was to determine the surface gene sequence in ADV-resistant patients carrying the A181T/V mutation and to describe the clinical significance. Of the 22 patients included in this study, 13 were ADV-resistant with rtA181T/V mutations (polymerase mutation group, Group P) and nine were antiviral treatment-naïve (control group, Group C). The Pre-S1 gene mutation, V60A, was detected in 11 patients (Group P=8, Group C=3). A start codon mutation in the Pre-S2 gene was found in five patients (Group P=3, Group C=2). An S gene mutation, sA184V, was found in nine patients, all of whom were in group P. Although sW172stop and sL173F mutations were detected, reduced HBsAg titer was not observed. Further study of these mutations and their clinical implications are needed. |
format | Text |
id | pubmed-2811294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-28112942010-02-01 Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations Kim, Jeong Han Jung, Young Kul Joo, Moon Kyung Kim, Ji Hoon Yim, Hyung Joon Park, Jong-Jae Kim, Jae Seon Bak, Young-Tae Yeon, Jong Eun Byun, Kwan Soo J Korean Med Sci Original Article The hepatitis B virus (HBV) polymerase gene has overlapping reading frames with surface genes, which allows to alter the amino acid codon of the surface genes. In adefovir (ADV) treated chronic hepatitis B patients carrying rtA181T/rtA181V mutations, overlap with surface gene mutations such as sW172stop/sL173F has been reported. However, the clinical consequences of such surface mutations have not been determined. The aim of this study was to determine the surface gene sequence in ADV-resistant patients carrying the A181T/V mutation and to describe the clinical significance. Of the 22 patients included in this study, 13 were ADV-resistant with rtA181T/V mutations (polymerase mutation group, Group P) and nine were antiviral treatment-naïve (control group, Group C). The Pre-S1 gene mutation, V60A, was detected in 11 patients (Group P=8, Group C=3). A start codon mutation in the Pre-S2 gene was found in five patients (Group P=3, Group C=2). An S gene mutation, sA184V, was found in nine patients, all of whom were in group P. Although sW172stop and sL173F mutations were detected, reduced HBsAg titer was not observed. Further study of these mutations and their clinical implications are needed. The Korean Academy of Medical Sciences 2010-02 2009-01-19 /pmc/articles/PMC2811294/ /pubmed/20119580 http://dx.doi.org/10.3346/jkms.2010.25.2.257 Text en © 2010 The Korean Academy of Medical Sciences. http://jkms.org/index.php?main=terms This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0 (http://jkms.org/index.php?main=terms) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Jeong Han Jung, Young Kul Joo, Moon Kyung Kim, Ji Hoon Yim, Hyung Joon Park, Jong-Jae Kim, Jae Seon Bak, Young-Tae Yeon, Jong Eun Byun, Kwan Soo Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations |
title | Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations |
title_full | Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations |
title_fullStr | Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations |
title_full_unstemmed | Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations |
title_short | Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations |
title_sort | hepatitis b viral surface mutations in patients with adefovir resistant chronic hepatitis b with a181t/v polymerase mutations |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811294/ https://www.ncbi.nlm.nih.gov/pubmed/20119580 http://dx.doi.org/10.3346/jkms.2010.25.2.257 |
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