Use of Aripiprazole in Clozapine Induced Enuresis: Report of Two Cases

This report describes the efficacy of combined use of aripiprazole in the treatment of a patient with clozapine induced enuresis. Aripiprazole acts as a potential dopamine partial agonist and the dopamine blockade in the basal ganglia might be one of the causes of urinary incontinence and enuresis....

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Detalles Bibliográficos
Autores principales: Lee, Myung-Ji, Kim, Chul-Eung
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811310/
https://www.ncbi.nlm.nih.gov/pubmed/20119596
http://dx.doi.org/10.3346/jkms.2010.25.2.333
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author Lee, Myung-Ji
Kim, Chul-Eung
author_facet Lee, Myung-Ji
Kim, Chul-Eung
author_sort Lee, Myung-Ji
collection PubMed
description This report describes the efficacy of combined use of aripiprazole in the treatment of a patient with clozapine induced enuresis. Aripiprazole acts as a potential dopamine partial agonist and the dopamine blockade in the basal ganglia might be one of the causes of urinary incontinence and enuresis. We speculate that aripiprazole functioned as a D2 agonist in hypodopaminergic state of basal ganglia caused by clozapine and maintained dopamine level that would improve enuresis ultimately.
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spelling pubmed-28113102010-02-01 Use of Aripiprazole in Clozapine Induced Enuresis: Report of Two Cases Lee, Myung-Ji Kim, Chul-Eung J Korean Med Sci Case Report This report describes the efficacy of combined use of aripiprazole in the treatment of a patient with clozapine induced enuresis. Aripiprazole acts as a potential dopamine partial agonist and the dopamine blockade in the basal ganglia might be one of the causes of urinary incontinence and enuresis. We speculate that aripiprazole functioned as a D2 agonist in hypodopaminergic state of basal ganglia caused by clozapine and maintained dopamine level that would improve enuresis ultimately. The Korean Academy of Medical Sciences 2010-02 2010-01-19 /pmc/articles/PMC2811310/ /pubmed/20119596 http://dx.doi.org/10.3346/jkms.2010.25.2.333 Text en © 2010 The Korean Academy of Medical Sciences. http://jkms.org/index.php?main=terms This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0 (http://jkms.org/index.php?main=terms) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lee, Myung-Ji
Kim, Chul-Eung
Use of Aripiprazole in Clozapine Induced Enuresis: Report of Two Cases
title Use of Aripiprazole in Clozapine Induced Enuresis: Report of Two Cases
title_full Use of Aripiprazole in Clozapine Induced Enuresis: Report of Two Cases
title_fullStr Use of Aripiprazole in Clozapine Induced Enuresis: Report of Two Cases
title_full_unstemmed Use of Aripiprazole in Clozapine Induced Enuresis: Report of Two Cases
title_short Use of Aripiprazole in Clozapine Induced Enuresis: Report of Two Cases
title_sort use of aripiprazole in clozapine induced enuresis: report of two cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811310/
https://www.ncbi.nlm.nih.gov/pubmed/20119596
http://dx.doi.org/10.3346/jkms.2010.25.2.333
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